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Nitric Oxide Donor-Based Platinum Complexes as Potential Anticancer Agents.
MedLine Citation:
PMID:  23015473     Owner:  NLM     Status:  Publisher    
Joining forces: Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound (carboplatin), thus suggesting an interesting synergy between the ability of the nitrate-based ligands to release nitric oxide and the ability of the platinum moiety to inhibit DNA synthesis.
Jian Zhao; Shaohua Gou; Yanyan Sun; Runting Yin; Zhimei Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Chemistry (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1521-3765     ISO Abbreviation:  Chemistry     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513783     Medline TA:  Chemistry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381.
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