| Nitric Oxide Donor-Based Platinum Complexes as Potential Anticancer Agents. | |
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MedLine Citation:
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PMID: 23015473 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Joining forces: Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound (carboplatin), thus suggesting an interesting synergy between the ability of the nitrate-based ligands to release nitric oxide and the ability of the platinum moiety to inhibit DNA synthesis. |
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Authors:
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Jian Zhao; Shaohua Gou; Yanyan Sun; Runting Yin; Zhimei Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: Chemistry Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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