Document Detail


Nitric Oxide Donor Agents for the Treatment of Ischemia/Reperfusion Injury in Human Subjects: A Systematic Review.
MedLine Citation:
PMID:  23358103     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: In animal models, administration of nitric oxide (NO) donor agents has been shown to reduce ischemia/reperfusion (I/R) injury. Our aim was to systematically analyze the biomedical literature to determine the effects of NO-donor agent administration on I/R injury in human subjects. We hypothesized that NO-donor agents reduce I/R injury. METHODS: We performed a search of Cochrane Library, PUBMED, CINHAL, conference proceedings, and other sources with no restriction to language using a comprehensive strategy. Study inclusion criteria were: (1) human subjects; (2) documented periods of ischemia and reperfusion; (3) treatment arm comprised of NO-donor agent administration; and (4) use of a control arm. We excluded secondary reports, reviews, correspondence, and editorials. We performed a qualitative analysis to collate and summarize treatment effects according to the recommended methodology from the Cochrane Handbook. RESULTS: Twenty-six studies involving multiple etiologies of I/R injury (10 cardiopulmonary bypass, 6 organ transplant, 7 myocardial infarction, 3 limb tourniquet) met all inclusion and no exclusion criteria. Six of 26 (23%) were considered high quality studies as per the Cochrane criteria for assessing risk of bias. In 20/26 (77%) studies, and 4/6 (67%) high-quality studies, patients treated with NO-donor agents experienced reduced I/R injury compared to controls. Zero clinical studies to date have tested NO-donor agent administration in patients with cerebral I/R injury (e.g. cardiac arrest, stroke). CONCLUSION: Despite a paucity of high-quality clinical investigations, the preponderance of evidence to date suggests that administration of NO-donor agents may be an effective treatment for I/R injury in human subjects.
Authors:
Brian W Roberts; Jessica Mitchell; J Hope Kilgannon; Michael E Chansky; Stephen Trzeciak
Related Documents :
11216973 - Early mortality and morbidity of bilateral versus single internal thoracic artery revas...
23052973 - Cardiac magnetic resonance imaging of rapid vcam-1 up-regulation in myocardial ischemia...
17515963 - Factor xiiia-v34l and factor xiiib-h95r gene variants: effects on survival in myocardia...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-25
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Emergency Medicine (BWR, JM, JHK, MEC, ST), and the Department of Medicine, Division of Critical Care Medicine (ST), Cooper University Hospital, Camden, New Jersey, USA. JM, Mitchell-Jessica@cooperhealth.edu; JHK, Kilgannon-Hope@cooperhealth.edu; MEC, Chansky-Michael@cooperhealth.edu; ST, Trzeciak-Stephen@cooperhealth.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Expressions of Thymidylate Synthase,Thymidine Phosphorylase, Class III ?-tubulin, and Excision Repai...
Next Document:  Relationship Power As a Mediator of Intimate Partner Violence and Mental Health Issues Among Incarce...