| Nitrergic stimulation of the locus coeruleus modulates blood pressure and heart rate in the anaesthetized rat. | |
| | |
MedLine Citation:
|
PMID: 10366019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To investigate whether nitric oxide is involved in the cardiovascular responses mediated via the locus coeruleus, the effects of microinjections of L-arginine and L-glutamate into the locus coeruleus on blood pressure and heart rate were investigated in sodium pentobarbitone-anaesthetized rats. Unilateral microinjection of L-arginine (25, 50 nmol) elicited dose-related depressor (-17 +/- 4, -25 +/- 4 mmHg) and bradycardic (13 +/- 3, 24 +/- 6 b.p.m.) effects. Furthermore, these effects were attenuated by prior local microinjection of N(G)-nitro-L-arginine (40 nmol). Peripheral muscarinic receptor blockade with atropine methyl nitrate (1 mg/kg, i.v.) attenuated the bradycardic but not the depressor responses to L-arginine. L-Glutamate (2 nmol) microinjections also mediated depressor (-27 +/- 6 mmHg) and bradycardic (53 +/- 23 b.p.m.) effects that were attenuated by microinjections of dizocilpine maleate (1 nmol) into the locus coeruleus. In addition, pretreatment with N(G)-nitro-L-arginine (40 nmol) also significantly attenuated the depressor response elicited by L-glutamate. These results suggest that nitrergic and glutamatergic pathways are operative within the locus coeruleus to modulate cardiovascular function, and also that a functional interaction may exist between the nitrergic and glutamatergic systems within the rat locus coeruleus. |
| | |
Authors:
|
S T Yao; D I Finkelstein; A J Lawrence |
Related Documents
:
|
15183509 - Repeated application of ketamine to rats induces changes in the hippocampal expression ... 8955519 - Modulation of extracellular glutamate concentration by nitric oxide synthase inhibitor ... 9038939 - Nitric oxide-dependent and -independent norepinephrine release in rat mesenteric arteries. 15288439 - Different response to exogenous l-arginine in nitric oxide production between hippocamp... 8742019 - Effects of nitric oxide donors sodium nitroprusside and 3-morpholino-sydnonimine on pro... 11850659 - Hemodynamic responses to papaverine: do nitric oxide, cyclic gmp, or calcium mediate th... 9061779 - Changes of behavior and monoamine metabolites in the rat brain after repeated methamphe... 8281529 - Accelerated glycolysis in early hypertensive left ventricular hypertrophy. 23076629 - Bacopa monnieri and l-deprenyl differentially enhance the activities of antioxidant enz... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroscience Volume: 91 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1999 |
Date Detail:
|
Created Date: 1999-08-02 Completed Date: 1999-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 621-9 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Monash University, Clayton, Victoria, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, General Animals Arginine / administration & dosage, pharmacology* Atropine / pharmacology Blood Pressure / drug effects, physiology* Dizocilpine Maleate / pharmacology Functional Laterality Glutamic Acid / administration & dosage, pharmacology* Heart Rate / drug effects, physiology* Locus Coeruleus / drug effects, physiology* Male Microinjections Nitroarginine / administration & dosage, pharmacology* Rats Rats, Inbred WKY |
| Chemical | |
Reg. No./Substance:
|
2149-70-4/Nitroarginine; 51-55-8/Atropine; 56-86-0/Glutamic Acid; 74-79-3/Arginine; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blockade of cannabinoid receptors by SR141716 selectively increases Fos expression in rat mesocortic...
Next Document: Effects of ammonia in vitro on endogenous taurine efflux and cell volume in rat cerebrocortical mini...