| Nitrendipine versus hydrochlorothiazide in hypertensive patients over 70 years of age. | |
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MedLine Citation:
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PMID: 2920503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of nitrendipine and hydrochlorothiazide were studied in hypertensive elderly patients. Blood pressure was reduced (p less than 0.01) by both nitrendipine (13/10 +/- 4/3 mm Hg [n = 15], mean +/- SE) and hydrochlorothiazide (25/11 +/- 4/2 mm Hg [n = 16]). After hydrochlorothiazide, plasma glucose, uric acid, and renin activity increased and plasma potassium levels decreased. Edema and flushing were the main adverse reactions during nitrendipine. The response of blood pressure and heart rate to head-up tilt were not significantly different under both treatments. However, the effects of both drugs on diastolic blood pressure and norepinephrine responses to head-up tilt differed significantly. We conclude that, in the elderly, hydrochlorothiazide lowers systolic blood pressure more effectively than nitrendipine. However, nitrendipine does not have any of the potentially harmful metabolic side effects that were found during hydrochlorothiazide therapy. The clinical significance of a lower vasoreactivity during nitrendipine, as was found with the head-up tilt test, has to be established. |
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Authors:
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R W Jansen; H J Van Lier; W H Hoefnagels |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 45 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-14 Completed Date: 1989-04-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-8 Citation Subset: AIM; IM; S |
Affiliation:
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Department of Medicine, University Hospital Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Body Weight Double-Blind Method Female Heart Rate / drug effects Hemodynamics / drug effects Humans Hydrochlorothiazide / adverse effects, therapeutic use* Hypertension / blood, drug therapy* Hypotension, Orthostatic / chemically induced Male Nitrendipine / adverse effects, therapeutic use* Random Allocation |
| Chemical | |
Reg. No./Substance:
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39562-70-4/Nitrendipine; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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