Document Detail

Nitrendipine-stimulated release of prostacyclin-like substance in normal and atherosclerotic animals.
MedLine Citation:
PMID:  3300663     Owner:  NLM     Status:  MEDLINE    
Nitrendipine (Bayotensin) is a dihydropyridine derivative that appears to preferentially dilate peripheral vessels by a cellular mechanism similar to those found with other calcium blocking agents. In this study nitrendipine when infused (0.2-0.3 mg/kg i.v.) into anaesthetized cats caused a release of a substance disaggregating platelet clumps which had adhered to blood superfused collagen strip. The appearance of this unstable disaggregating substance was prevented by the pretreatment of cats with acetylsalicylic acid (50 mg/kg i.v.). In atherosclerotic rabbits nitrendipine stimulated release of prostacyclin-like substance without effect on proaggregatory concentrations of arachidonic acid and adenosine diphosphate. In rats nitrendipine inhibited the development of atherosclerotic changes in the aorta evoked by the atherogenic diet with ergocalciferol (vitamin D2). It is suggested that nitrendipine may promote formation of prostacyclin in arteries and inhibit the development of atherosclerosis.
L Grodzińska; M Basista; E Basista; M Sławiński; J Swies; J Stachura; R Ohlrogge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  37     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-31     Completed Date:  1987-07-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  412-5     Citation Subset:  IM    
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MeSH Terms
Arteriosclerosis / metabolism*
Epoprostenol / biosynthesis,  metabolism*
Nitrendipine / pharmacology*
Platelet Aggregation / drug effects
Rats, Inbred Strains
Species Specificity
Reg. No./Substance:
35121-78-9/Epoprostenol; 39562-70-4/Nitrendipine

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