| Nitrendipine-stimulated release of prostacyclin-like substance in normal and atherosclerotic animals. | |
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MedLine Citation:
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PMID: 3300663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrendipine (Bayotensin) is a dihydropyridine derivative that appears to preferentially dilate peripheral vessels by a cellular mechanism similar to those found with other calcium blocking agents. In this study nitrendipine when infused (0.2-0.3 mg/kg i.v.) into anaesthetized cats caused a release of a substance disaggregating platelet clumps which had adhered to blood superfused collagen strip. The appearance of this unstable disaggregating substance was prevented by the pretreatment of cats with acetylsalicylic acid (50 mg/kg i.v.). In atherosclerotic rabbits nitrendipine stimulated release of prostacyclin-like substance without effect on proaggregatory concentrations of arachidonic acid and adenosine diphosphate. In rats nitrendipine inhibited the development of atherosclerotic changes in the aorta evoked by the atherogenic diet with ergocalciferol (vitamin D2). It is suggested that nitrendipine may promote formation of prostacyclin in arteries and inhibit the development of atherosclerosis. |
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Authors:
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L Grodzińska; M Basista; E Basista; M Sławiński; J Swies; J Stachura; R Ohlrogge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 37 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-07-31 Completed Date: 1987-07-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 412-5 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / metabolism* Cats Diet Epoprostenol / biosynthesis, metabolism* Female Male Nitrendipine / pharmacology* Platelet Aggregation / drug effects Rats Rats, Inbred Strains Species Specificity |
| Chemical | |
Reg. No./Substance:
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35121-78-9/Epoprostenol; 39562-70-4/Nitrendipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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