Document Detail

Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells.
MedLine Citation:
PMID:  2940606     Owner:  NLM     Status:  MEDLINE    
Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells. Using a method of forming both dehydrated cells and irreversibly sickled cells in vitro by repeated cycles of sickling and unsickling, the effects of several drugs in inhibiting the formation of these cells were studied. Drugs known as Ca2+ channel antagonists, such as nitrendipine, nifedipine and verapamil were found to inhibit these reactions. Other types of calcium channel blockers, such as lanthanum and zinc, did not inhibit the formation of these cells. The potency of drugs to inhibit irreversibly sickled cell formation was related to the potency of inhibition of calmodulin-activated phosphodiesterase.
S T Ohnishi; K Y Horiuchi; K Horiuchi; M E Jurman; K K Sadanaga
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  32     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-01     Completed Date:  1986-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  248-56     Citation Subset:  IM    
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MeSH Terms
Anemia, Sickle Cell / blood*
Calcium / blood
Calcium Channel Blockers / pharmacology*
Calmodulin / physiology
Dehydration / blood
Erythrocytes, Abnormal / drug effects*,  metabolism
Lanthanum / pharmacology
Nifedipine / analogs & derivatives,  pharmacology
Phosphodiesterase Inhibitors
Potassium / blood
Verapamil / pharmacology
Zinc / pharmacology
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Calmodulin; 0/Phosphodiesterase Inhibitors; 21829-25-4/Nifedipine; 39562-70-4/Nitrendipine; 52-53-9/Verapamil; 7439-91-0/Lanthanum; 7440-09-7/Potassium; 7440-66-6/Zinc; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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