Document Detail


Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria.
MedLine Citation:
PMID:  8743519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment. Twenty-eight valid patients [13 with nitrendipine (N) and 15 with enalapril (E) with NIDDM, hypertension (diastolic blood pressure between 90 to 114 mm Hg) and MA (urinary albumin between 30 to 300 mg/24 hr) were recruited in a double blind, randomized trial. Following a placebo run-in period of two to four weeks, all eligible patients were randomly allocated to either N or E treatment. Treatment lasted six months, with two different visits at three and six months in which blood pressure (BP), heart rate (HR), renal function and MA were measured. No statistically significant differences on BP and metabolic parameters were found between both treatment groups. The geometric mean of final glomerular filtration rate (GFR) in the N group was 34.5% higher than in the E group, while the reduction on MA was most important in the E group. Eleven patients reported adverse events (AEs) and there were four dropouts, three of them due to AEs. We conclude that both treatments are a good choice for treating diabetic hypertensive patients with early altered renal function, as they reduce BP without altering metabolic parameters, increase GFR and reduce MA with a low frequency of AEs.
Authors:
C Piñol; A Cobos; A Cases; E Esmatges; J Soler; J Closas; R Pascual; J Planas
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Kidney international. Supplement     Volume:  55     ISSN:  0098-6577     ISO Abbreviation:  Kidney Int. Suppl.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-20     Completed Date:  1996-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508622     Medline TA:  Kidney Int Suppl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S85-7     Citation Subset:  IM    
Affiliation:
Hospital Clínic i Provincial, Hospitals Comarcals de Catalunya, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Albuminuria / etiology
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  therapeutic use*
Blood Glucose / metabolism
Blood Pressure / drug effects
Calcium Channel Blockers / adverse effects,  therapeutic use*
Diabetes Mellitus, Type 2 / complications*
Diabetic Nephropathies / prevention & control
Double-Blind Method
Enalapril / adverse effects,  therapeutic use*
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy*,  etiology,  urine
Kidney Function Tests
Male
Middle Aged
Nitrendipine / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Calcium Channel Blockers; 39562-70-4/Nitrendipine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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