| Nitrendipine and atenolol in essential hypertension in young and middle-aged patients: effect on serum lipids and left ventricular mass. | |
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MedLine Citation:
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PMID: 1723446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to compare the antihypertensive efficacy of nitrendipine and atenolol in young and middle-aged patients with mild or moderate essential hypertension and to assess treatment effects on plasma lipids and potential changes in left ventricular mass (LVM). After 2 weeks off medication and a 4-week placebo phase, patients who met the inclusion criteria [sitting diastolic blood pressure (DBP) 95 to 114 mm Hg, age below 50 years] entered a 12-week dose-adjustment and maintenance period with nitrendipine or atenolol. Serum lipids were determined before and after therapy. At the same time, LVM was evaluated echocardiographically (M mode). Twenty-two patients completed the double-blind, randomized study. After 12 weeks on nitrendipine, the systolic blood pressure (SBP) and DBP were reduced (p less than 0.005 and p less than 0.001, respectively). No significant changes in heart rate were observed. There were no changes in the lipid profile, and LVM was reduced from 93.7 to 23.4 to 82.4 +/- 22.6 g/m2 of body surface (p less than 0.05). On atenolol the SBP and DBP were reduced (p less than 0.001 and p less than 0.001, respectively). The expected reduction in heart rate was significant (p less than 0.05). Total cholesterol and LDL cholesterol increased by 11% (p less than 0.05) and 12.3% (p less than 0.01), respectively. HDL cholesterol showed a small reduction. Tryglycerides increased by 22% (n.s.). LVM did not change. In conclusion, nitrendipine and atenolol showed comparable antihypertensive efficacy.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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N C López; J L Corral; L A Rincón; M R Arreaza; J Giralt; G A Galué; Y E Barrios; I Arocha |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 18 Suppl 1 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-03-10 Completed Date: 1992-03-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S101-5 Citation Subset: IM |
Affiliation:
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Unidad de Hipertensión Arterial, Hospital Central de Maracay, Venezuela. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atenolol / adverse effects, therapeutic use* Blood Pressure / drug effects, physiology Double-Blind Method Female Heart Rate / drug effects, physiology Heart Ventricles / drug effects* Humans Hypertension / drug therapy*, physiopathology Lipids / blood* Male Middle Aged Nitrendipine / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 29122-68-7/Atenolol; 39562-70-4/Nitrendipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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