Document Detail

Nitrates, arterial function, wave reflections and coronary heart disease.
MedLine Citation:
PMID:  17075217     Owner:  NLM     Status:  MEDLINE    
This chapter traces the history of nitroglycerin from the initial nitration of glycerol to its widespread clinical use. The pharmacologic differences between nitroglycerin and nitric oxide are described, as well as their similar mechanisms of action. The vasoactivity of nitroglycerin requires a biochemical transformation, the nature of which remains incompletely understood. This poorly defined mechanism probably also relates to the phenomenon of nitroglycerin tolerance. By increasing the distensibility of muscular arteries, nitroglycerin slows pulse wave velocity, reduces wave reflections and alters the shape of the aortic pulse. This alteration reduces the systolic blood pressure and left ventricular after load and helps to explain the usefulness of nitroglycerin in angina pectoris, congestive heart failure and isolated systolic hypertension.
Harold Smulyan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in cardiology     Volume:  44     ISSN:  0065-2326     ISO Abbreviation:  Adv Cardiol     Publication Date:  2007  
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270063     Medline TA:  Adv Cardiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  302-14     Citation Subset:  IM    
Department of Medicine, Upstate Medical University, Syracuse, NY 13120, USA.
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MeSH Terms
Arteries / drug effects,  physiopathology
Blood Pressure / drug effects
Coronary Disease / drug therapy*,  metabolism,  physiopathology
Endothelium, Vascular / drug effects,  physiopathology
Endothelium-Dependent Relaxing Factors / metabolism
Hypertension / drug therapy
Nitric Oxide / metabolism*,  pharmacology
Nitro Compounds / pharmacology
Nitroglycerin / pharmacology*
Vascular Resistance / drug effects
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Endothelium-Dependent Relaxing Factors; 0/Nitro Compounds; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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