Document Detail


Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators.
MedLine Citation:
PMID:  16887803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitroalkene derivatives of linoleic acid (LNO2) and oleic acid (OA-NO2) are present; however, their biological functions remain to be fully defined. Herein, we report that LNO2 and OA-NO2 inhibit lipopolysaccharide-induced secretion of proinflammatory cytokines in macrophages independent of nitric oxide formation, peroxisome proliferator-activated receptor-gamma activation, or induction of heme oxygenase-1 expression. The electrophilic nature of fatty acid nitroalkene derivatives resulted in alkylation of recombinant NF-kappaB p65 protein in vitro and a similar reaction with p65 in intact macrophages. The nitroalkylation of p65 by fatty acid nitroalkene derivatives inhibited DNA binding activity and repressed NF-kappaB-dependent target gene expression. Moreover, nitroalkenes inhibited endothelial tumor necrosis factor-alpha-induced vascular cell adhesion molecule 1 expression and monocyte rolling and adhesion. These observations indicate that nitroalkenes such as LNO2 and OA-NO2, derived from reactions of unsaturated fatty acids and oxides of nitrogen, are a class of endogenous anti-inflammatory mediators.
Authors:
Taixing Cui; Francisco J Schopfer; Jifeng Zhang; Kai Chen; Tomonaga Ichikawa; Paul R S Baker; Carlos Batthyany; Balu K Chacko; Xu Feng; Rakesh P Patel; Anupam Agarwal; Bruce A Freeman; Yuqing E Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-08-03
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  281     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-09     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35686-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*
Bone Marrow Cells / metabolism
Fatty Acids / chemistry*
Heme Oxygenase (Decyclizing) / genetics
Macrophages / metabolism
Mice
Mice, Knockout
NF-kappa B / chemistry
Nitrogen / chemistry
PPAR gamma / metabolism
Protein Processing, Post-Translational
Recombinant Proteins / chemistry
Signal Transduction*
Grant Support
ID/Acronym/Agency:
HL068878/HL/NHLBI NIH HHS; HL075397/HL/NHLBI NIH HHS; HL58115/HL/NHLBI NIH HHS; HL64937/HL/NHLBI NIH HHS; HL70146/HL/NHLBI NIH HHS; R01 HL058115/HL/NHLBI NIH HHS; R01 HL058115-09/HL/NHLBI NIH HHS; R01 HL064937/HL/NHLBI NIH HHS; R01 HL064937-05A1/HL/NHLBI NIH HHS; S06GM08248/GM/NIGMS NIH HHS; T32HL07457/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Fatty Acids; 0/NF-kappa B; 0/PPAR gamma; 0/Recombinant Proteins; EC 1.14.99.3/Heme Oxygenase (Decyclizing); N762921K75/Nitrogen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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