| Nitrate tolerance as a possible cause of multidrug-resistant coronary artery spasm. | |
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MedLine Citation:
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PMID: 20558913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary spasm can usually be controlled by administration of Ca antagonists. However, there are some cases of coronary spasm whose attacks cannot be controlled even with large doses of Ca antagonist and/or its combination with nitrates. Here we describe the case of a 41-year-old man whose attacks of coronary spasm were resistant to the combined administration of nitrates, Ca antagonists, and a statin. The attacks were alleviated and disappeared after withdrawal of nitrates and recurred after readministration of a nitroglycerin patch. The involvement of nitrate tolerance in the pathogenesis of multidrug resistant coronary spasm was revealed and its implication discussed. |
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Authors:
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Yoshinobu Morikawa; Yuji Mizuno; Eisaku Harada; Osamu Kuboyama; Michihiro Yoshimura; Hirofumi Yasue |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International heart journal Volume: 51 ISSN: 1349-2365 ISO Abbreviation: Int Heart J Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244240 Medline TA: Int Heart J Country: Japan |
Other Details:
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Languages: eng Pagination: 211-3 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcium Channel Blockers / adverse effects Coronary Vasospasm / chemically induced*, diagnosis*, therapy Drug Resistance, Multiple Drug Tolerance / physiology* Humans Male Nitrates / adverse effects* Nitroglycerin / adverse effects Vasodilator Agents / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Nitrates; 0/Vasodilator Agents; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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