Document Detail

Nithsdale Schizophrenia Surveys 23: movement disorders. 20-year review.
MedLine Citation:
PMID:  12411269     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the past 10 years the new atypical antipsychotic drugs have stimulated further interest in the pharmacological management of schizophrenia. The risk of movement disorders has been reported to be less with these new agents. AIMS: To examine the current prevalence of movement disorders among all people with schizophrenia in a discrete geographical area, to compare the prevalence in patients receiving and not receiving atypical antipsychotic drugs; and to compare current prevalence with prevalence over the past 20 years. METHOD: In Nithsdale, south-west Scotland, in 1999/2000, we replicated previous studies by using the Abnormal Involuntary Movements Scale, Simpson-Angus scale and Barnes Akathisia Rating Scale to measure tardive dyskinesia, parkinsonism and akathisia, respectively. Mental state was assessed by the Positive and Negative Syndrome Scale. RESULTS: In 136 patients the prevalence of probable tardive dyskinesia was 43%, of parkinsonism 35% and of akathisia 15%. Parkinsonism was present as often in those receiving atypicals as in those receiving standard oral antipsychotics. The prevalence of tardive dyskinesia has doubled over 20 years. CONCLUSIONS: Movement disorders remain significant problems for patients despite the introduction of atypical antipsychotic drugs.
Jennifer Halliday; Susan Farrington; Shiona Macdonald; Tom MacEwan; Val Sharkey; Robin McCreadie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  181     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2002-12-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Department of Clinical Research, Crichton Royal Hospital, Dumfries, UK.
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MeSH Terms
Akathisia, Drug-Induced / epidemiology,  etiology
Antipsychotic Agents / adverse effects*
Dyskinesia, Drug-Induced / epidemiology*,  etiology*
Health Surveys
Middle Aged
Parkinsonian Disorders / chemically induced,  epidemiology
Risk Factors
Schizophrenia / drug therapy*
Scotland / epidemiology
Reg. No./Substance:
0/Antipsychotic Agents

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