Document Detail

Nippostrongylus brasiliensis: histochemical changes in the composition of mucins in goblet cells during infection in rats.
MedLine Citation:
PMID:  3338549     Owner:  NLM     Status:  MEDLINE    
Changes in the quality of mucins in jejunal goblet cells were investigated during an infection with Nippostrongylus brasiliensis in rats. At 10 days after infection, when proliferative activity in the crypts is excessive and both crypts and villi are characterized by hyperplasia of goblet cells, the histochemical composition of the population of goblet cells in comparison with controls shows a marked increase in crypt and villous goblet cells containing neutral mucins. At 15 days after infection both crypts and villi display a significant increase in goblet cells containing acid mucin and decrease in goblet cells containing neutral mucin. The acid mucins in crypt and villous goblet cells on day 15 appear to be sulphomucins predominantly, whereas in controls sialomucin-containing goblet cells dominate both in the crypts and on the villi. These experiments establish that the explusion of N. brasiliensis from the intestine of the rat coincides not only with quantitative, but also with remarkable qualitative changes in the histochemical composition of mucins in goblet cells.
J F Koninkx; M H Mirck; H G Hendriks; J M Mouwen; J E van Dijk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental parasitology     Volume:  65     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-02     Completed Date:  1988-03-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
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MeSH Terms
Intestinal Mucosa / metabolism,  pathology
Jejunum / metabolism,  pathology*
Mucins / metabolism*
Nematode Infections / metabolism*,  pathology
Reg. No./Substance:

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