| The nipple-areola complex epidermis: a prospective systematic study in adult autopsies. | |
| | |
MedLine Citation:
|
PMID: 20802299 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The prevalence of different types of clear cells and of the mite Demodex in the nipple-areola complex of adult autopsies of both sexes not suffering from breast cancer was studied in a total of 140 nipples. The epidermis of the nipple-areola complex shows squamous cells and 3 types of clear cells: Toker cells, pagetoid dyskeratosis cells, and signet ring-like cells. Toker cells were identified by standard light microscopy in 13 of 140 nipples (9.3%). Reactivity of these cells for CK7 was observed in 35 nipples (25%). They are derived from the lactiferous duct epithelium. Pagetoid dyskeratosis cells were identified in 56 of 140 nipples (40%). In 12 nipples, these cells were conspicuous (8.6%). It is suggested that the proliferation of these cells is induced by friction. Signet ring-like cells were identified in 71 nipples (50.7%). In 2 nipples, these cells were conspicuous (1.4%). They are a consequence of artefact related to formalin fixation. The prevalence of all these clear cells has no relationship with gender. Routine histopathological examination is usually enough to distinguish the characteristic features of the clear cells involving the nipple epidermis and permits differentiation of other entities with epidermal pale cells. Demodex mites were observed in 58 nipple-areola complexes (41.4%). They were more common in male nipple-areola complexes (P < 0.05). The prevalence of these mites was seen to remain steady along the years since the third decade. Demodex mites are common parasites of human nipple and are apparently of no pathologic significance. |
| | |
Authors:
|
José Fernando Val-Bernal; Cristina Diego; Diana Rodriguez-Villar; María Francisca Garijo |
Related Documents
:
|
15900119 - Vulvar clear cells of toker: precursors of extramammary paget's disease. 17904119 - Rac1 activity regulates proliferation of aggressive metastatic melanoma. 1822769 - Melanin-related biochemistry of igr 1 human melanoma cells. 18770749 - Reporters of gene expression: autofluorescent proteins. 7604979 - Ultrastructural and histochemical studies of the epiphyseal plate in normal chicks. 7923219 - A potential marker protease of invasiveness, seprase, is localized on invadopodia of hu... 3788959 - Kinetic analysis in single, intact cells by microspectrophotometry: evidence for two po... 21769539 - Estimation of glucose uptake by ovarian follicular cells. 18759129 - Inhibition of protein deacetylation by trichostatin a impairs microtubule-kinetochore a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American Journal of dermatopathology Volume: 32 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
|
Languages: eng Pagination: 787-93 Citation Subset: IM |
Affiliation:
|
Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain. apavbj@humv.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartme...
Next Document: Acquired lymphangiectasias in genital lichen sclerosus.