| Nine-year incidence of open-angle glaucoma in the Barbados Eye Studies. | |
| | |
MedLine Citation:
|
PMID: 17397925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To determine the 9-year incidence of open-angle glaucoma (OAG) in African-descent participants of the Barbados Eye Studies. DESIGN: Nine-year cohort study with 81% to 85% participation. PARTICIPANTS: Three thousand two hundred twenty-two persons without definite OAG at baseline, at risk of developing OAG at follow-up. METHODS: The standardized protocol included automated perimetry and various ophthalmic measurements, with a comprehensive ophthalmologic examination for those referred. Fundus photographs were evaluated independently by masked graders. Incidence was estimated by the product-limit approach. Relative risk (RR) ratios with 95% confidence intervals (CIs) were based on Cox regression models with discrete time. MAIN OUTCOME MEASURE: Nine-year incidence of definite OAG, based on the development of visual field defects and glaucomatous optic neuropathy, with ophthalmologic confirmation. RESULTS: The 9-year incidence of definite OAG was 4.4% (95% CI, 3.7%-5.2%), or an average of 0.5%/year, based on 125 new cases. Incidence increased greatly with age, from 2.2% at ages 40 to 49 years to 7.9% at ages 70 years or older, and tended to be higher in men than women (4.9% vs. 4.1%; RR, 1.3; 95% CI, 0.9-1.8). More than half (53%) of new cases were undetected, and of these, one third had intraocular pressure of 21 mmHg or less. When 141 persons developing suspected/probable OAG were considered, the total incidence was 9.4% (8.4%-10.6%), averaging approximately 1%/year, also increasing with age, and significantly higher in men than women (10.7% vs. 8.6%; RR, 1.31; 95% CI, 1.02-1.67). CONCLUSIONS: These new data provide a measure of the long-term risk of OAG in an African-descent population, which is markedly higher than in persons of European ancestry. Results confirm the increased risk with age and in men. The incidence data fill a gap in our understanding of OAG risk and have implications for public health policy and planning; they also will allow the study of factors related to the risk of OAG development. |
| | |
Authors:
|
M Cristina Leske; S Y Wu; R Honkanen; B Nemesure; A Schachat; L Hyman; A Hennis; |
Related Documents
:
|
9391505 - Incidence estimates of late stages of trachoma among women in a hyperendemic area of ce... 21476175 - Social support and sense of belonging as protective factors in the rumination-depressiv... 8436895 - Education, reading, and familial tendency as risk factors for myopia in hong kong fishe... 12598445 - How big is the burden of visual loss caused by age related macular degeneration in the ... 20409655 - Short-term surgical outcome and safety of risk reducing salpingo-oophorectomy in brca1/... 8426835 - Second generation follow-up of the danish perinatal study women: study design and facto... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-03-30 |
Journal Detail:
|
Title: Ophthalmology Volume: 114 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-06-04 Completed Date: 2007-06-19 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
|
Languages: eng Pagination: 1058-64 Citation Subset: IM |
Affiliation:
|
Department of Preventive Medicine, Stony Brook University, Stony Brook, New York 11794-8036, USA. cleske@notes.cc.sunysb.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult African Continental Ancestry Group / ethnology* Aged Aged, 80 and over Barbados / epidemiology Female Glaucoma, Open-Angle / diagnosis, ethnology* Humans Incidence Intraocular Pressure Longitudinal Studies Male Middle Aged Perimetry Risk Factors Tonometry, Ocular Vision Disorders / diagnosis Visual Fields |
| Grant Support | |
ID/Acronym/Agency:
|
EY07617/EY/NEI NIH HHS; EY07625/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Randomized comparison of the intraocular pressure-lowering effect of phacoviscocanalostomy and phaco...
Next Document: Frequency doubling perimetry and short-wavelength automated perimetry to detect early glaucoma.