Document Detail

Nine-year changes in intraocular pressure: the Barbados Eye Studies.
MedLine Citation:
PMID:  17102013     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe temporal changes in intraocular pressure (IOP) and associated risk factors after 9 years of follow-up in a population of African descent. METHODS: Changes in IOP were evaluated in 2298 participants without glaucoma or IOP-lowering treatment at baseline. Risk factor analyses used a multiple regression approach with mixed effects, which accounted for intereye correlation. RESULTS: The mean 9-year change in IOP was small, with relatively large dispersion (mean +/- SD, 0.4 +/- 4.0 mm Hg). Only 6.5% of persons with IOP of 21 mm Hg or less at baseline had elevated IOP greater than 21 mm Hg after 9 years. Mean IOP increases were largest in persons aged 50 to 59 years at baseline (mean +/- SD, 0.9 +/- 4.3 mm Hg), whereas IOP decreased in persons 70 years or older (mean +/- SD, -0.6 +/- 4.2 mm Hg). In multivariate analyses, IOP changes were positively associated with male sex, hypertension, diabetes history, and higher systolic and diastolic blood pressure at baseline, as well as with increases in blood pressure throughout 9 years (P<.05). CONCLUSIONS: After long-term follow-up, minimal changes in IOP were observed in this African-origin population. The consistent relationships of hypertension and diabetes to IOP, a major glaucoma risk factor, underscore the public health importance of controlling these systemic conditions in black populations, where glaucoma incidence is high.
Sun-Yuh Wu; Barbara Nemesure; Anselm Hennis; M Cristina Leske;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  124     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-14     Completed Date:  2006-12-04     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1631-6     Citation Subset:  AIM; IM    
Department of Preventive Medicine, Stony Brook University, Stony Brook, NY 11794-8036, USA.
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MeSH Terms
African Continental Ancestry Group*
Barbados / epidemiology
Blood Pressure
Diabetes Complications / complications,  ethnology
Follow-Up Studies
Glaucoma, Open-Angle / ethnology,  etiology
Hypertension / complications,  ethnology
Intraocular Pressure*
Middle Aged
Ocular Hypertension / ethnology*,  etiology
Risk Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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