Document Detail


Nimodipine, a voltage-sensitive calcium channel antagonist, fails to ameliorate light-induced retinal degeneration in rat.
MedLine Citation:
PMID:  1947437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent study demonstrated the amelioration of light-induced photoreceptor degeneration by flunarizine and suggested that the protective effect achieved by the drug may be due to the inhibition of inositol 1,4,5-trisphosphate-induced calcium release from intracellular stores or the inhibition of calcium entry through putative voltage-sensitive calcium channels. In the current study, we investigated the effect of nimodipine, a specific voltage-sensitive calcium channel blocker, in light-induced retinal degeneration to further define the factors involved in the retinal degenerative process. Morphological, morphometric, and biochemical results demonstrated that nimodipine was ineffective in ameliorating light-induced retinal degeneration, and implied that calcium entry through voltage-sensitive channels is unlikely to be involved in this disease process, and inositol 1,4,5-trisphosphate-induced calcium release from intracellular stores may play a dominant role in light-induced photoreceptor cell damage.
Authors:
J P Li; D P Edward; T T Lam; M O Tso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  72     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-12-13     Completed Date:  1991-12-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of Illinois, Chicago College of Medicine 60612.
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MeSH Terms
Descriptor/Qualifier:
Animals
Light
Male
Nimodipine / metabolism,  pharmacology*
Rats
Rats, Inbred Lew
Retina / chemistry,  drug effects,  pathology*
Retinal Degeneration / pathology*
Rhodopsin / analysis
Chemical
Reg. No./Substance:
66085-59-4/Nimodipine; 9009-81-8/Rhodopsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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