Document Detail

Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats.
MedLine Citation:
PMID:  8778878     Owner:  NLM     Status:  MEDLINE    
Single-unit recordings in anesthetized animals revealed that the L-type calcium channel antagonist, nimodipine (10 mg/kg), attenuated the activation of locus coeruleus neurons produced by naltrexone in opiate-dependent rats. Nimodipine also dose-dependently (1 mg/kg, 10 mg/kg, IP) inhibited the display of naloxone-precipitated withdrawal behaviors with a time course similar to that of nimodipine effects on the locus coeruleus. These data suggest that nimodipine may suppress opiate withdrawal via noradrenergic mechanisms.
J H Krystal; S Compere; E J Nestler; K Rasmussen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  59     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:    1996 Apr-May
Date Detail:
Created Date:  1996-09-13     Completed Date:  1996-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  863-6     Citation Subset:  IM    
VA-Yale Alcoholism Research Center, VA Medical Center, West Haven, CT 06516, USA.
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MeSH Terms
Calcium Channel Blockers / pharmacology*
Dose-Response Relationship, Drug
Locus Coeruleus / drug effects,  physiology*
Morphine Dependence / psychology*
Naltrexone / antagonists & inhibitors*,  pharmacology
Narcotic Antagonists / pharmacology*
Nimodipine / pharmacology*
Norepinephrine / physiology
Rats, Sprague-Dawley
Substance Withdrawal Syndrome / psychology*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Narcotic Antagonists; 16590-41-3/Naltrexone; 51-41-2/Norepinephrine; 66085-59-4/Nimodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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