Document Detail


Nimodipine promotes regeneration and functional recovery after intracranial facial nerve crush.
MedLine Citation:
PMID:  11477600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The calcium flow inhibitor, nimodipine, has been shown to promote motor neuron survival in the facial nucleus after intracranial facial nerve transection. However, it has not been known whether the neuroprotective effects primarily involve survival of nerve cell bodies or outgrowth and/or myelination of nerve fibers. Here, we studied the effects of nimodipine in a different injury model in which the facial nerve was unilaterally crushed intracranially. This lesion caused complete anterograde degeneration and partial retrograde degeneration that were studied with a combination of several stereological methods. Nimodipine did not attenuate the modest lesion-induced neuronal loss (13%) but accelerated the time course of functional recovery and axonal regrowth, inducing increased numbers and sizes of myelinated axons in the facial nerve. It is interesting to note that nimodipine also enlarged the axons and the myelin sheaths in the nonlesioned facial nerve, which points to the possibility of using this substance for new clinical applications to promote axonal growth and remyelination.
Authors:
P Mattsson; A M Janson; H Aldskogius; M Svensson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  437     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-30     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-17     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Hospital, SE-171 76 Stockholm, Sweden. per.mattsson@ks.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies
Calcium Channel Blockers / pharmacology*
Calcium Channels / physiology
Calcium Channels, L-Type / analysis,  immunology
Cell Count
Facial Nerve Injuries / drug therapy*,  physiopathology
Immunohistochemistry
Male
Motor Neurons / chemistry,  physiology,  ultrastructure
Movement / physiology
Nerve Crush
Nerve Fibers, Myelinated / physiology
Nerve Regeneration / drug effects*
Nimodipine / pharmacology*
Rats
Rats, Sprague-Dawley
Vibrissae / innervation,  physiology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Calcium Channel Blockers; 0/Calcium Channels; 0/Calcium Channels, L-Type; 66085-59-4/Nimodipine

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