Document Detail


Nimodipine: a new calcium antagonistic drug with a preferential cerebrovascular action.
MedLine Citation:
PMID:  7102417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nimodipine, isopropyl (2-methoxy-ethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, is a new calcium antagonistic vasodilator with a preferential effect on brain vessels. Nimodipine prevents spasm of the isolated rabbit basilar artery produced both by depolarization and by receptor stimulation. In peripheral vessels nimodipine does not inhibit agonistically induced contractions. In vivo nimodipine also dilates predominantly cerebral vessels; peripheral vasodilation resulting in a decrease in blood pressure is much less pronounced. Nimodipine prevents the impaired reperfusion of the brain caused by a transitory global cerebral ischaemia. Nimodipine is predicted to be useful in the prophylaxis and treatment of cerebral vasospasm in humans.
Authors:
S Kazda; R Towart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  63     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Basilar Artery / drug effects
Blood Vessels / drug effects
Calcium Channel Blockers / therapeutic use*
Humans
Ischemic Attack, Transient / drug therapy*
Nicotinic Acids / pharmacology,  therapeutic use*
Nimodipine
Rabbits
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Nicotinic Acids; 66085-59-4/Nimodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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