Document Detail

Nimodipine maintains in vivo the increase in GFAP and enhances the astroglial ensheathment of surviving motoneurons in the rat following permanent target deprivation.
MedLine Citation:
PMID:  9192289     Owner:  NLM     Status:  MEDLINE    
Facial and hypoglossal nerves were resected unilaterally in a total of 108 rats. Rats were divided into two groups; one group received standard food pellets (placebo), the other received food pellets containing the Ca(2+)-blocking agent nimodipine. The expression of glial fibrillary acidic protein was examined in paraffin sections of the brainstem using light microscopical immunocytochemistry, and the degree of glial process ensheathment of the surviving neuronal perikarya in the hypoglossal and facial nuclei quantified on electron micrographs. Up to 28 days post-axotomy no differences in glial fibrillary acidic protein-immunoreactivity were observed between placebo and nimodipine-treated animals. By 42-56 days, glial fibrillary acid protein-immunoreactivity was stronger in the nimodipine treated animals and by 112 days, glial fibrillary acid protein-immunoreactive astrocytes occurred only in nimodipine-treated animals. Thin astrocytic processes were seen to ensheath neurons in both placebo and nimodipine-treated animals. By 28 days post axotomy, lesioned neurons in nimodipine treated animals were covered by a mean of 2.6 (hypoglossal) and 2.9 (facial nucleus) astrocytic lamellae, compared with 1.7 lamellae in the placebo group. This relatively greater ensheathment of hypoglossal and facial neurons was maintained up to 112 days post-lesion, but reduced in the placebo-treated group to approximately 1.4 lamellae. It is concluded that nimodipine enhances the formation of astrocytic lamellae on lesioned neurons and that this process may be associated with a protective role for activated astrocytes directed towards motoneurons suffering from permanent target-deprivation.
O Guntinas-Lichius; F Martinez-Portillo; J Lebek; D N Angelov; E Stennert; W F Neiss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurocytology     Volume:  26     ISSN:  0300-4864     ISO Abbreviation:  J. Neurocytol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364620     Medline TA:  J Neurocytol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  IM    
Hals-, Nasen- und Ohrenklinik, Universität zu Köln, Germany.
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MeSH Terms
Astrocytes / metabolism,  ultrastructure*
Calcium Channel Blockers / pharmacology*
Facial Nerve / surgery,  ultrastructure
Glial Fibrillary Acidic Protein / metabolism*
Hypoglossal Nerve / surgery,  ultrastructure
Microscopy, Electron
Motor Neurons / metabolism,  ultrastructure*
Nimodipine / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Glial Fibrillary Acidic Protein; 0/Placebos; 66085-59-4/Nimodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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