Document Detail

Nimodipine can diminish oxidative stress in patients with severe head trauma.
MedLine Citation:
PMID:  22854593     Owner:  NLM     Status:  In-Data-Review    
AIM: Antioxidative effect of nimodipine was investigated in patient with severe head trauma.
METHODS: The patients in group A were treated according to the standard procedures without nimodipine. Other patients in group B were treated with standard procedures plus intravenous nimodipine for a week. Three times per day, blood samples were taken from internal jugular venous saturation probe and central venous catheter for a week. The levels of malondialdehyde (MDA), reduced glutathione (GSH), nitrite, and nitrate, ascorbic acid, retinol and β-carotene in the serum were measured. RESULS: MDA levels in group B were significantly lower than those in the group A (P<0.05). As for GSH levels, it was observed that there was a significant increase in GSH levels in group B when compared to those in group A (P<0.01). Comparison of nitrate and nitrite levels in the serum of patient groups showed that these parameters were significantly higher in group B than those in group A (P<0.01). It was seen that there were a significant increase in ascorbic acid (P<0.01) and β-carotene (P<0.05) levels in group B when compared to those in group A. Values of retinol levels were slightly higher in group B than that of group A, and there was no significant difference between the groups.
CONCLUSION: Severe head trauma may increase oxidative stress. Administration of nimodipine may prevent the oxidative stress and may augment endogenous antioxidative defense systems in patients with severe head trauma.
A Aslan; M Gurelik; M Cemek; M Buyukokuroglu; H M Goksel; O Eser
Related Documents :
15482413 - Effectiveness of interferon beta treatment in relapsing-remitting multiple sclerosis: a...
22325333 - Window replacement and residential lead paint hazard control 12 years later.
1914613 - Effect of oxygen therapy on increasing arterial oxygen tension in hypoxemic patients wi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgical sciences     Volume:  56     ISSN:  0390-5616     ISO Abbreviation:  J Neurosurg Sci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0432557     Medline TA:  J Neurosurg Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Department of Neurosurgery, Faculty of Medicine, Afyon Kocatepe UniversityAfyonkarahisar, Turkey -
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Survival prognostic factors in patients with glioblastoma: our experience.
Next Document:  Intraosseous hemangioma of the clivus: a case report and review of the literature.