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Nimodipine can diminish oxidative stress in patients with severe head trauma.
MedLine Citation:
PMID:  22854593     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: Antioxidative effect of nimodipine was investigated in patient with severe head trauma.
METHODS: The patients in group A were treated according to the standard procedures without nimodipine. Other patients in group B were treated with standard procedures plus intravenous nimodipine for a week. Three times per day, blood samples were taken from internal jugular venous saturation probe and central venous catheter for a week. The levels of malondialdehyde (MDA), reduced glutathione (GSH), nitrite, and nitrate, ascorbic acid, retinol and β-carotene in the serum were measured. RESULS: MDA levels in group B were significantly lower than those in the group A (P<0.05). As for GSH levels, it was observed that there was a significant increase in GSH levels in group B when compared to those in group A (P<0.01). Comparison of nitrate and nitrite levels in the serum of patient groups showed that these parameters were significantly higher in group B than those in group A (P<0.01). It was seen that there were a significant increase in ascorbic acid (P<0.01) and β-carotene (P<0.05) levels in group B when compared to those in group A. Values of retinol levels were slightly higher in group B than that of group A, and there was no significant difference between the groups.
CONCLUSION: Severe head trauma may increase oxidative stress. Administration of nimodipine may prevent the oxidative stress and may augment endogenous antioxidative defense systems in patients with severe head trauma.
Authors:
A Aslan; M Gurelik; M Cemek; M Buyukokuroglu; H M Goksel; O Eser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgical sciences     Volume:  56     ISSN:  0390-5616     ISO Abbreviation:  J Neurosurg Sci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0432557     Medline TA:  J Neurosurg Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Faculty of Medicine, Afyon Kocatepe UniversityAfyonkarahisar, Turkey - aaslan71@yahoo.com.
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