| Nimesulide-induced fulminant hepatitis. | |
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MedLine Citation:
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PMID: 14655069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 18-year-old boy was brought to the hospital with jaundice, confusion, abdominal discomfort and distension. He had a history of oral intake of nimesulide for three days. Clinical and laboratory findings were compatible with fulminant hepatitis. Exclusion of other causes of liver injury strongly favored drug-induced toxicity. All of the signs, symptoms and laboratory abnormalities returned to normal after cessation of the nimesulide and supportive treatment, and he was discharged on the 15th day after admission. This case differs from the other cases in the literature regarding the time of onset, and indicates that nimesulide may induce fulminant hepatitis in the first few days of administration. Therefore, patients receiving nimesulide should be frequently monitored with serial serum transaminases, beginning from the first week of intake. |
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Authors:
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Orhan Ozgür; Arif Hacihasanoğlu; S Sami Karti; Ercüment Ovali |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology Volume: 14 ISSN: 1300-4948 ISO Abbreviation: Turk J Gastroenterol Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-12-05 Completed Date: 2004-02-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9515841 Medline TA: Turk J Gastroenterol Country: Turkey |
Other Details:
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Languages: eng Pagination: 208-10 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. ozgur@ktu.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Inflammatory Agents, Non-Steroidal / adverse effects*, therapeutic use Combined Modality Therapy Follow-Up Studies Humans Liver Failure / chemically induced*, therapy Liver Function Tests Male Risk Assessment Severity of Illness Index Sulfonamides / adverse effects*, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfonamides; 51803-78-2/nimesulide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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