Document Detail


Nimesulide-induced fulminant hepatitis.
MedLine Citation:
PMID:  14655069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An 18-year-old boy was brought to the hospital with jaundice, confusion, abdominal discomfort and distension. He had a history of oral intake of nimesulide for three days. Clinical and laboratory findings were compatible with fulminant hepatitis. Exclusion of other causes of liver injury strongly favored drug-induced toxicity. All of the signs, symptoms and laboratory abnormalities returned to normal after cessation of the nimesulide and supportive treatment, and he was discharged on the 15th day after admission. This case differs from the other cases in the literature regarding the time of onset, and indicates that nimesulide may induce fulminant hepatitis in the first few days of administration. Therefore, patients receiving nimesulide should be frequently monitored with serial serum transaminases, beginning from the first week of intake.
Authors:
Orhan Ozgür; Arif Hacihasanoğlu; S Sami Karti; Ercüment Ovali
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology     Volume:  14     ISSN:  1300-4948     ISO Abbreviation:  Turk J Gastroenterol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9515841     Medline TA:  Turk J Gastroenterol     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  208-10     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. ozgur@ktu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Combined Modality Therapy
Follow-Up Studies
Humans
Liver Failure / chemically induced*,  therapy
Liver Function Tests
Male
Risk Assessment
Severity of Illness Index
Sulfonamides / adverse effects*,  therapeutic use
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfonamides; 51803-78-2/nimesulide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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