Document Detail


Nimesulide and indomethacin induce apoptosis in head and neck cancer cells.
MedLine Citation:
PMID:  15482327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to inhibit the enzyme cyclooxygenase (COX). There are two isoforms of the enzyme. Recent investigations indicate that both isoforms, COX-1 and COX-2, are involved in carcinogenesis. METHODS: We investigated the effects of nimesulide, a COX-2 selective and indomethacin, a non-selective NSAID on the head and neck squamous cell carcinoma (HNSCC) cell lines SCC-9 and SCC-25. Effects on cell numbers and apoptosis were assayed by cell counting, immunofluorescence and fluorescence activated cell sorting (FACS). COX expression was examined by Western blotting. RESULTS: The investigated cell lines express COX-1 and COX-2. Nimesulide and indomethacin induce apoptosis and cause a reduction of cell number. Incubation with NSAIDs upregulated COX-2 expression. CONCLUSION: The results of our study on HNSCC cells together with data from different studies showing anti-cancer activity of NSAIDs suggest that COX inhibitors could play a role in HNSCC treatment and prevention.
Authors:
Martina Pelzmann; Dietmar Thurnher; Claudia Gedlicka; Helga Martinek; Birgit Knerer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  33     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-14     Completed Date:  2004-12-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  607-13     Citation Subset:  D; IM    
Affiliation:
Department of Otorhinolaryngology, University of Vienna, Währinger Gürtel, Vienna, Austria. martina.pelzmann@aon.at
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Apoptosis / drug effects*
Blotting, Western
Carcinoma, Squamous Cell / enzymology*
Cell Proliferation / drug effects
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / pharmacology*
Flow Cytometry
Fluorescent Antibody Technique, Indirect
Head and Neck Neoplasms / enzymology*
Humans
Indomethacin / pharmacology*
Isoenzymes / antagonists & inhibitors,  biosynthesis*
Membrane Proteins
Prostaglandin-Endoperoxide Synthases / biosynthesis*
Sulfonamides / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Membrane Proteins; 0/Sulfonamides; 51803-78-2/nimesulide; 53-86-1/Indomethacin; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS1 protein, human; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

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