Document Detail

Nigrostriatal dysfunction in patients with amyotrophic lateral sclerosis and parkinsonism.
MedLine Citation:
PMID:  21167502     Owner:  NLM     Status:  In-Data-Review    
The pathomechanism of amyotrophic lateral sclerosis (ALS) with parkinsonism (ALS-P) has not been clarified. We report two patients with ALS-P who showed dysfunction of the nigrostriatal system. The first patient showed tremor dominant, asymmetric parkinsonism which was more severe on the right side, while the second patient exhibited predominant freezing of gait. Both patients showed reduced uptake of [(18)F] N-(3-fluoropropyl)-2ß-carbon ethoxy-3ß-(4-iodophenyl) nortropane ((18)F-FP-CIT) in the posterior parts of bilateral putamina on positron emission tomography (PET). Based on our PET findings, we suggest that presynaptic nigrostriatal dysfunction may be involved in the pathomechanism of parkinsonism combined with ALS.
Hee Kyung Park; Young-Min Lim; Jae Seung Kim; Myoung C Lee; Seung Min Kim; Bum Joon Kim; Kwang-Kuk Kim
Publication Detail:
Type:  Journal Article     Date:  2010-12-16
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  301     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  12-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Neurology, Inje University Ilsan-Paik Hospital, Goyang, Republic of Korea.
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