| Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. | |
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MedLine Citation:
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PMID: 20350768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1beta induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1beta expression can trigger and systemic IL-1beta exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD. |
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Authors:
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Mar?a Clara Pott Godoy; Carina Cintia Ferrari; Fernando Juan Pitossi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-29 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 222 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-39 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of Regenerative and Protective Therapies of the Nervous System, Foundation Leloir Institute, IIBBA-CONICET, 435, Av Patricias Argentinas, (1405) Buenos Aires, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics Animals Anti-Inflammatory Agents / pharmacology, therapeutic use Corpus Striatum / immunology, pathology, physiopathology Dexamethasone / pharmacology, therapeutic use Disease Models, Animal Dopamine / metabolism Encephalitis / drug therapy, genetics, immunology* Genetic Vectors / adverse effects Gliosis / drug therapy, genetics, immunology Interleukin-1beta / genetics*, metabolism, toxicity* Male Movement Disorders / drug therapy, genetics, immunology Nerve Degeneration / drug therapy, genetics, immunology* Neural Pathways / immunology, pathology, physiopathology Neurons / immunology, metabolism, pathology Parkinsonian Disorders / drug therapy, genetics, immunology* Rats Rats, Wistar Substantia Nigra / immunology*, pathology, physiopathology Transfection / methods Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Interleukin-1beta; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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