Document Detail

Night blood pressure and cigarette smoking: disparate association in healthy subjects and diabetic patients.
MedLine Citation:
PMID:  7704286     Owner:  NLM     Status:  MEDLINE    
Cigarette smoking and diabetes are well known risk factors for cardiovascular disease. The relation of nocturnal blood pressure (BP) to cigarette smoking is unclarified. We examined ambulatory BP in 18 healthy smokers matched for sex and age to 18 non-smokers. Sixteen smoking type 1 diabetic patients matching 16 non-smoking patients with normal urinary albumin excretion were also investigated. None of the healthy subjects or diabetic patients had a clinic BP > 160/95 mmHg. Night BP (systolic/diastolic mmHg) in healthy smokers (mean +/- SD) 102 +/- 9/57 +/- 5 was lower than in healthy non-smokers 108 +/- 10/61 +/- 6 (p = 0.06/p < 0.05). The difference between smokers and non-smokers was most prominent in the 3 h period just before rising (99 +/- 9/57 +/- 6 versus 108 +/- 8/62 +/- 7, p < 0.01/p < 0.05). Daytime BP was similar between groups. The night/day ratio (%) of systolic (84 +/- 7) and diastolic (74 +/- 7) BP in healthy smokers was lower than in non-smokers (88 +/- 5 versus 80 +/- 5, p < 0.05 and p < 0.01) indicating an altered diurnal rhythm of blood pressure. No statistical significant difference was found for night or day BP in diabetic smokers versus non-smokers. The finding of a significantly lower BP in healthy (supine) smokers at night speaks against dysautonomia explaining the lower clinic BP found in epidemiological studies, as recently proposed. Alternatively a rebound effect or the existence of a substance with vasodilating properties in non-diabetic smokers is suggested.(ABSTRACT TRUNCATED AT 250 WORDS)
K W Hansen; M M Pedersen; J S Christiansen; C E Mogensen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  3     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-05-08     Completed Date:  1995-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  381-8     Citation Subset:  IM    
Medical Department M (Diabetes & Endocrinology), Aarhus University Hospital, Denmark.
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MeSH Terms
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm*
Diabetes Mellitus, Type 1 / complications,  physiopathology*
Hemoglobin A, Glycosylated / analysis
Life Style
Middle Aged
Smoking / physiopathology*
Sympathetic Nervous System / physiopathology
Vasodilator Agents / pharmacokinetics
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Vasodilator Agents

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