Document Detail

Night blindness, yellow vision, and yellow skin: symptoms and signs of malabsorption.
MedLine Citation:
PMID:  16705527     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Rapidly progressing bilateral night blindness in an elderly patient suggests primarily a diagnosis of paraneoplastic retinopathy. Occasionally diffuse rod dysfunction can result from vitamin A deficiency. HISTORY AND SIGNS: A 70-year-old man complained of progressive night blindness and xanthopsia for the past 6 months. Visual acuity was 0.8 in both eyes with severe dyschromatopsia. Slit-lamp and fundus examination were normal. Visual field disclosed bilateral depression. Scotopic full-field ERG was severely reduced. The patient's medical history revealed an acute pancreatitis one year ago, followed by chronic jaundice and an increased blood bilirubin. Serum vitamin A level was decreased to 0.1 micromol/L (normal range 1.5 to 4.0). THERAPY AND OUTCOME: Intramuscular injections of vitamin A were provided. Subjective visual improvement was reported already one day after initiation of therapy. Scotopic full-field ERG was markedly improved 3 days after the injection and was only slightly subnormal 3 months later. CONCLUSIONS: In developed countries, vitamin A deficiency usually results from malabsorption syndromes and manifests initially by rod more than cone dysfunction. This diagnosis should be entertained early as vitamin A supplementation induces a rapid restoration of vision.
E Pitchon; O Sahli; F-X Borruat
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Klinische Monatsblätter für Augenheilkunde     Volume:  223     ISSN:  0023-2165     ISO Abbreviation:  Klin Monbl Augenheilkd     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-07-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0014133     Medline TA:  Klin Monbl Augenheilkd     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Department of Neuro-Ophtalmology, Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland.
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MeSH Terms
Color Vision Defects / prevention & control*
Malabsorption Syndromes / diagnosis,  drug therapy*
Night Blindness / prevention & control*
Pigmentation Disorders / prevention & control*
Skin Pigmentation
Vitamin A / administration & dosage*
Vitamin A Deficiency / drug therapy*
Xerophthalmia / prevention & control*
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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