| Nifedipine or verapamil counteracts hypertension in gravid ewes. | |
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MedLine Citation:
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PMID: 3752569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension frequently complicates endotracheal intubation in the severely preeclamptic parturient. The calcium entry-blocking drugs nifedipine (N) and verapamil (V) are effective antihypertensive agents in nonpregnant patients. The authors studied the maternal and fetal hemodynamic effects of these drugs in chronically instrumented gravid ewes made hypertensive with an infusion of norepinephrine (NE). Initially NE was infused to increase maternal mean arterial pressure (MAP) by 20%. The NE infusion was continued and either N, 2 mg, or V, 10 mg, was administered intravenously. MAP decreased promptly to control values following both drugs. Maternal heart rate (MHR) decreased significantly following NE infusion. MHR returned to control values following V administration, and increased significantly above control following N administration. Uterine blood flow decreased 50-60% during NE infusion, and there was no further change following either N or V. Fetal hemodynamics were unchanged throughout the study. These results suggest that both N and V may be effective antihypertensive agents in the parturient. V did not produce maternal tachycardia and may be the preferable drug. |
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Authors:
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M C Norris; J C Rose; D M Dewan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 65 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-10-15 Completed Date: 1986-10-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 254-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Female Hypertension / drug therapy* Nifedipine / therapeutic use* Norepinephrine / diagnostic use Pre-Eclampsia / drug therapy* Pregnancy Regional Blood Flow Sheep Uterus / blood supply Verapamil / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine; 51-41-2/Norepinephrine; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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