Document Detail

Nifedipine or verapamil counteracts hypertension in gravid ewes.
MedLine Citation:
PMID:  3752569     Owner:  NLM     Status:  MEDLINE    
Hypertension frequently complicates endotracheal intubation in the severely preeclamptic parturient. The calcium entry-blocking drugs nifedipine (N) and verapamil (V) are effective antihypertensive agents in nonpregnant patients. The authors studied the maternal and fetal hemodynamic effects of these drugs in chronically instrumented gravid ewes made hypertensive with an infusion of norepinephrine (NE). Initially NE was infused to increase maternal mean arterial pressure (MAP) by 20%. The NE infusion was continued and either N, 2 mg, or V, 10 mg, was administered intravenously. MAP decreased promptly to control values following both drugs. Maternal heart rate (MHR) decreased significantly following NE infusion. MHR returned to control values following V administration, and increased significantly above control following N administration. Uterine blood flow decreased 50-60% during NE infusion, and there was no further change following either N or V. Fetal hemodynamics were unchanged throughout the study. These results suggest that both N and V may be effective antihypertensive agents in the parturient. V did not produce maternal tachycardia and may be the preferable drug.
M C Norris; J C Rose; D M Dewan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  65     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Gas Analysis
Hypertension / drug therapy*
Nifedipine / therapeutic use*
Norepinephrine / diagnostic use
Pre-Eclampsia / drug therapy*
Regional Blood Flow
Uterus / blood supply
Verapamil / therapeutic use*
Reg. No./Substance:
21829-25-4/Nifedipine; 51-41-2/Norepinephrine; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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