| Nifedipine retard in the treatment of hypertension. A study using ambulatory blood pressure recordings. | |
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MedLine Citation:
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PMID: 2289219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The subjects were 24 patients, aged 37 to 66 years, with mild to moderate hypertension, treated with nifedipine retard (mean dose, 47 mg daily) for 7 to 16 weeks. The mean 24-hour ambulatory blood pressure (BP) declined significantly from 158/101 before treatment to 136/87 mmHg after treatment. Daytime BP declined from 160/101 to 133/86 mmHg and nighttime BP from 152/98 to 132/85 mmHg; the diurnal variation in diastolic BP was lost during treatment with nifedipine. The consecutive hourly BPs were all significantly lower after treatment. BPs in response to physiologic tests were significantly reduced after treatment. Heart rate increased significantly during treatment. Side effects (palpitations, pedal edema, and flushing of the face) were reported by four patients. It is concluded that nifedipine retard is safe and effective in the treatment of mild to moderate hypertension. |
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Authors:
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Y S Hwang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical therapeutics Volume: 12 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1990 Nov-Dec |
Date Detail:
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Created Date: 1991-03-29 Completed Date: 1991-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 503-12 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ambulatory Care Blood Pressure / drug effects Blood Pressure Determination Delayed-Action Preparations Female Heart Rate / drug effects Humans Hypertension / drug therapy* Male Middle Aged Monitoring, Physiologic Nifedipine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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