Document Detail

Nifedipine potentiates gabapentin antinociception in rats.
MedLine Citation:
PMID:  12500503     Owner:  NLM     Status:  MEDLINE    
To evaluate the involvement of Ca++ channels in Gabapentin antinociception. In healthy male albino rats formalin (50 microliters, 5%) was injected at the planter surface of the paw. Pain score was calculated. Antinociceptive effect of (10, 30 mg/kg) gabapentin and (3, 10 mg/kg) nifedipine alone and on co-administration of sub analgesic doses was studied 30 minutes after formalin injection and reduction in pain scores was calculated. Gabapentin (30 mg/kg) and nifedipine (10 mg/kg) reduced the pain score in formalin injected rats. Gabapentin (10 mg/kg) and nifedipine (3 mg/kg) given alone did not modify pain score, however, on co-administration they significantly reduced the pain score. Study provides evidence of involvement of Ca++ channels in gabapentin antinociception.
R K Dixit; V K Bhargava
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  46     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-12-25     Completed Date:  2003-05-20     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  249-51     Citation Subset:  IM    
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh-160 012.
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MeSH Terms
Acetates / pharmacology*
Analgesics / pharmacology*
Cyclohexanecarboxylic Acids*
Drug Synergism
Nifedipine / pharmacology*
Pain Measurement / drug effects*,  methods
Rats, Wistar
gamma-Aminobutyric Acid*
Reg. No./Substance:
0/Acetates; 0/Amines; 0/Analgesics; 0/Cyclohexanecarboxylic Acids; 21829-25-4/Nifedipine; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

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