Document Detail

Nifedipine in the treatment of hypertension in the elderly.
MedLine Citation:
PMID:  3998199     Owner:  NLM     Status:  MEDLINE    
The effect of nifedipine monotherapy, retard tablets, 20 mg bid, was evaluated in 23 hypertensive patients, mean age, 79 +/- 2 years. Twenty-one patients completed an eight-week study. Blood pressure (BP) decreased to 160/90 mm Hg in 15 patients; in four additional patients diastolic BP dropped by 15% to 28%. In a subset of five patients with isolated systolic hypertension, a significant reduction in systolic BP was noted. Side effects were relatively mild and only two patients discontinued the study. The results suggest that nifedipine monotherapy offers an alternative, logic, therapeutic approach to hypertension in the elderly.
J Stessman; B Leibel; Y Yagil; R Eliakim; D Ben-Ishay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  25     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-07-18     Completed Date:  1985-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
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MeSH Terms
Age Factors
Blood Pressure / drug effects
Hypertension / drug therapy*
Nifedipine / adverse effects,  therapeutic use*
Time Factors
Reg. No./Substance:

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