| Nifedipine gastrointestinal therapeutic system--hypertension management to improve cardiovascular outcomes. | |
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MedLine Citation:
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PMID: 16115193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is a major cardiovascular risk factor, and its increasing prevalence is of great clinical concern. Despite the availability of numerous effective therapies, hypertension remains under-diagnosed and under-treated. Hypertension often coexists with other risk factors, and current guidelines recommend a multifactorial approach to management, with the aim of not only controlling blood pressure but also reducing overall cardiovascular risk. Nifedipine gastrointestinal therapeutic system (GITS) is a long-acting formulation of a calcium channel blocker. Once-daily dosing with nifedipine GITS has been shown to achieve smooth and continuous blood pressure control, identical to conventional first-line diuretic therapy. Small-scale clinical trials have also shown that nifedipine GITS positively affects markers of atherosclerotic disease, which may signify an additional clinical benefit, but this is yet to be demonstrated. The recently completed ACTION (A Coronary Disease Trial Investigating Outcome with Nifedipine GITS) trial provides further evidence that nifedipine GITS can be used safely in high-risk patients to treat angina, lower blood pressure and significantly improve clinical outcomes. |
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Authors:
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A M Heagerty |
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3209283 - Treatment of hypertensive emergencies with nifedipine. 1319413 - The reactivity of peripheral vessels of normo- and hypertensives. 9213203 - Assessment of antihypertensive effect by blood pressure monitoring: applications to bis... |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice Volume: 59 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-23 Completed Date: 2006-02-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 1112-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Manchester Royal Infirmary, Manchester, UK. tony.heagerty@manchester.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / therapeutic use* Calcium Channel Blockers / therapeutic use* Cardiovascular Diseases / prevention & control Drug Therapy, Combination Female Humans Hypertension / drug therapy* Male Middle Aged Nifedipine / therapeutic use* Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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