Document Detail

Nifedipine OROS in Chinese patients with hypertension - results of a post-marketing surveillance study in Taiwan.
MedLine Citation:
PMID:  16029996     Owner:  NLM     Status:  MEDLINE    
AIMS: This post-marketing surveillance study assessed the efficacy, safety, and tolerability of the treatment with nifedipine OROS in hypertensive patients in Taiwan. RESULTS: A total of 2044 patients were included in 204 outpatient clinics. Patients received 30 mg or 60 mg of nifedipine OROS. Mean treatment duration was 15.8 weeks. At endpoint, 91.4% of patients were receiving 30 mg nifedipine OROS. Mean blood pressure reduction was 20.6/10.3 mmHg; 46.1% of patients had a systolic blood pressure <140 mmHg and 66.8% had a diastolic blood pressure <90 mmHg. Total blood pressure control was achieved in 41.2% of all patients. Beta-blockers were the most commonly used (24.0%) concomitant antihypertensive therapy. A total of 2.3% of patients experienced adverse events. Subjective physicians' assessments of efficacy, tolerability, and patient acceptance of nifedipine OROS treatment had ratings of "very good" and "good" in 82.3% (efficacy), 87.5 (tolerability) and 88.1% (patient acceptance) of the study cohort. CONCLUSIONS: Nifedipine OROS proved to be effective and well tolerated for the treatment of hypertension in 2044 Chinese patients. The results confirm the findings and experience of previously performed controlled clinical studies.
Kwo-Chang Ueng; Zhih-Cheng Chen; Poh-Shiow Yeh; Kuo-Chun Hung; Shao-An Hu; Yi-Jen Hung; Harald Landen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure. Supplement     Volume:  14 Suppl 1     ISSN:  0803-8023     ISO Abbreviation:  Blood Press Suppl     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-20     Completed Date:  2009-01-28     Revised Date:  2010-05-18    
Medline Journal Info:
Nlm Unique ID:  9300787     Medline TA:  Blood Press Suppl     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Chung Shan Medical University Hospital, Institute of Medicine, Taichung, Taiwan.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Asian Continental Ancestry Group
Blood Pressure / drug effects*
Cohort Studies
Diastole / drug effects
Exanthema / chemically induced
Hypertension / drug therapy*,  ethnology
Middle Aged
Muscle Weakness / chemically induced
Nausea / chemically induced
Nifedipine / adverse effects,  therapeutic use*
Patient Satisfaction
Product Surveillance, Postmarketing / statistics & numerical data
Treatment Outcome
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Vasodilator Agents; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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