| Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport. | |
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MedLine Citation:
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PMID: 20809793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased blood cholesterol is an independent risk factor for atherosclerotic cardiovascular disease. Cholesterol homeostasis in the body is controlled mainly by endogenous synthesis, intestinal absorption, and hepatic excretion. Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes. It functions as a sterol transporter to mediate intestinal cholesterol absorption and counter-balances hepatobiliary cholesterol excretion. NPC1L1 is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that is widely used in treating hypercholesterolemia. Recent findings suggest that NPC1L1 deficiency or ezetimibe treatment also prevents diet-induced hepatic steatosis and obesity in addition to reducing blood cholesterol. Future studies should focus on molecular mechanisms underlying NPC1L1-dependent cholesterol transport and elucidation of how a cholesterol transporter modulates the pathogenesis of metabolic diseases. |
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Authors:
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Lin Jia; Jenna L Betters; Liqing Yu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of physiology Volume: 73 ISSN: 1545-1585 ISO Abbreviation: Annu. Rev. Physiol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-07-08 Revised Date: 2012-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0370600 Medline TA: Annu Rev Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 239-59 Citation Subset: IM |
Affiliation:
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Section on Lipid Sciences, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology Atherosclerosis / drug therapy, metabolism Azetidines / pharmacology Biliary Tract / drug effects, metabolism Biological Transport / drug effects, physiology Carrier Proteins / metabolism* Cholesterol / metabolism* Endocytosis / drug effects, physiology Fatty Liver / drug therapy, metabolism Humans Intestinal Absorption / drug effects, physiology Intestines / drug effects, metabolism* Liver / drug effects, metabolism* Membrane Proteins / genetics, metabolism* Mice Obesity / drug therapy, metabolism Phytosterols / metabolism Primates / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1F32DK084582-01/DK/NIDDK NIH HHS; R01DK085176/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Azetidines; 0/Carrier Proteins; 0/Membrane Proteins; 0/NPC1L1 protein, human; 0/Phytosterols; 163222-33-1/ezetimibe; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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