Document Detail


Nidal embolization of brain arteriovenous malformations using Onyx in 94 patients.
MedLine Citation:
PMID:  17353327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: To report our experience in the treatment of brain arteriovenous malformations (BAVMs) using Onyx (ev3, Irvine, Calif). Patients and METHODS: From January 1999 to October 2004, 94 patients with BAVMs were treated endovascularly in our department. They were 51 (54%) men and 43 (46%) women with a mean age of 32 years. A total of 210 endovascular procedures were performed with Onyx as the sole embolic agent in 88 procedures; Onyx and n-butyl cyanoacrylate (n-BCA) were used in combination in 50 procedures, and n-BCA alone was used in 72 procedures. RESULTS: The course of endovascular treatment was completed in 53 patients. In 26 patients (49%, 26/53) an angiographic cure was achieved using embolization as the sole therapeutic technique. Seven (13%, 7/53) patients underwent a surgical resection of the residual BAVM nidus, 20 (38%, 20/53) patients underwent radiosurgical treatment after nidal size reduction <2 cm was accomplished by endovascular treatment. Further endovascular treatment was planned in 33 patients, whereas in 5 patients, the continuation of embolization was aborted due to difficult nidus catheterization. Procedure-related permanent neurologic deficits were observed in 8 (8.5%, 8/94) patients. There were 3 procedure-related deaths. CONCLUSION: Onyx is suitable for brain BAVM embolizations and allows obtaining higher rates of anatomic cures compared with those obtained previously with other embolic agents.
Authors:
C Mounayer; N Hammami; M Piotin; L Spelle; G Benndorf; I Kessler; J Moret
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  28     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-13     Completed Date:  2007-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  518-23     Citation Subset:  IM    
Affiliation:
Department of Interventional Neuroradiology, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cerebral Angiography
Child
Child, Preschool
Cyanoacrylates / therapeutic use
Dimethyl Sulfoxide / therapeutic use*
Diplopia / etiology
Embolization, Therapeutic / adverse effects,  methods*,  mortality
Enbucrilate
Female
Follow-Up Studies
Humans
Intracranial Arteriovenous Malformations / mortality,  radiography,  therapy*
Male
Middle Aged
Ophthalmoplegia / etiology
Paresis / etiology
Polyvinyls / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cyanoacrylates; 0/Onyx copolymer; 0/Polyvinyls; 6606-65-1/Enbucrilate; 67-68-5/Dimethyl Sulfoxide

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