Document Detail

Nicotinic receptor signaling in nonexcitable cells.
MedLine Citation:
PMID:  12436417     Owner:  NLM     Status:  MEDLINE    
The finding that neuronal nicotinic acetylcholine receptors (nAChRs) are present in non-neuronal cells both within and outside the nervous system raises some interesting issues. The mechanisms underlying receptor signaling and its downstream consequences in these cells remain to be elucidated. Factors controlling the release of acetylcholine and the extent of its diffusion are likely to be different for these cells than for traditional neuronal synapses. Recent advances on the physiologic functions of some of these cell types have provided a better insight into possible functional roles for nAChRs in nonexcitable cells. The presence of nAChRs on these cells also implies a broader scope for the actions of nicotine that needs to be considered from a clinical viewpoint. Revealing the potential physiologic roles for nAChRs on nonexcitable cells is likely to provide a more complete understanding of cholinergic signaling.
Geeta Sharma; Sukumar Vijayaraghavan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of neurobiology     Volume:  53     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-18     Completed Date:  2003-01-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  524-34     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley Periodicals, Inc.
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, Colorado 80262, USA.
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MeSH Terms
Blood Cells / metabolism
Endothelium, Vascular / metabolism
Keratinocytes / metabolism
Neuroglia / metabolism
Receptors, Nicotinic / physiology*
Respiratory Mucosa / metabolism
Signal Transduction / physiology*
Grant Support
Reg. No./Substance:
0/Receptors, Nicotinic

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