| Nicotinic receptor signaling in nonexcitable cells. | |
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MedLine Citation:
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PMID: 12436417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The finding that neuronal nicotinic acetylcholine receptors (nAChRs) are present in non-neuronal cells both within and outside the nervous system raises some interesting issues. The mechanisms underlying receptor signaling and its downstream consequences in these cells remain to be elucidated. Factors controlling the release of acetylcholine and the extent of its diffusion are likely to be different for these cells than for traditional neuronal synapses. Recent advances on the physiologic functions of some of these cell types have provided a better insight into possible functional roles for nAChRs in nonexcitable cells. The presence of nAChRs on these cells also implies a broader scope for the actions of nicotine that needs to be considered from a clinical viewpoint. Revealing the potential physiologic roles for nAChRs on nonexcitable cells is likely to provide a more complete understanding of cholinergic signaling. |
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Authors:
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Geeta Sharma; Sukumar Vijayaraghavan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of neurobiology Volume: 53 ISSN: 0022-3034 ISO Abbreviation: J. Neurobiol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-18 Completed Date: 2003-01-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213640 Medline TA: J Neurobiol Country: United States |
Other Details:
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Languages: eng Pagination: 524-34 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley Periodicals, Inc. |
Affiliation:
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Department of Physiology and Biophysics, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, Colorado 80262, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cells / metabolism Endothelium, Vascular / metabolism Humans Keratinocytes / metabolism Mice Neuroglia / metabolism Receptors, Nicotinic / physiology* Respiratory Mucosa / metabolism Signal Transduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DA10266/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Nicotinic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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