| Nicotinic receptor-mediated effects on appetite and food intake. | |
| | |
MedLine Citation:
|
PMID: 12436425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus. |
| | |
Authors:
|
Young-Hwan Jo; David A Talmage; Lorna W Role |
Related Documents
:
|
18708095 - Triiodothyronine (t3) stimulates food intake via enhanced hypothalamic amp-activated ki... 19297235 - Ghrelin: a metabolic signal affecting the reproductive system. 19150635 - Purification and properties of ghrelin from the intestine of the goldfish, carassius au... 1494495 - Pituitary adenylate cyclase activating polypeptide (pacap) reduces food intake in mice. 22084625 - Repeated 24-hour recalls versus dietary records for estimating nutrient intakes in a na... 23605855 - Ochratoxin a and other mycotoxins in polish cereals and foods. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Journal of neurobiology Volume: 53 ISSN: 0022-3034 ISO Abbreviation: J. Neurobiol. Publication Date: 2002 Dec |
Date Detail:
|
Created Date: 2002-11-18 Completed Date: 2003-01-13 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0213640 Medline TA: J Neurobiol Country: United States |
Other Details:
|
Languages: eng Pagination: 618-32 Citation Subset: IM |
Copyright Information:
|
Copyright 2002 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Anatomy and Cell Biology, in the Center for Neurobiology and Behavior, Columbia, University, New York, NY 10032, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Appetite Regulation / drug effects*, physiology* Eating / drug effects*, physiology Humans Hypothalamus / drug effects* Nicotine / pharmacology* Receptors, Nicotinic / metabolism Smoking |
| Grant Support | |
ID/Acronym/Agency:
|
CA79737/CA/NCI NIH HHS; NS22061/NS/NINDS NIH HHS; NS29071/NS/NINDS NIH HHS; R01 NS022061-17/NS/NINDS NIH HHS; R01 NS022061-18/NS/NINDS NIH HHS; R01 NS022061-19/NS/NINDS NIH HHS; R01 NS022061-20/NS/NINDS NIH HHS; R01 NS022061-21/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Nicotinic; 54-11-5/Nicotine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cellular and synaptic mechanisms of nicotine addiction.
Next Document: Nicotinic receptor subtypes and cognitive function.