Document Detail


Nicotinic receptor-mediated effects on appetite and food intake.
MedLine Citation:
PMID:  12436425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus.
Authors:
Young-Hwan Jo; David A Talmage; Lorna W Role
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of neurobiology     Volume:  53     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-18     Completed Date:  2003-01-13     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-32     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley Periodicals, Inc.
Affiliation:
Department of Anatomy and Cell Biology, in the Center for Neurobiology and Behavior, Columbia, University, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / drug effects*,  physiology*
Eating / drug effects*,  physiology
Humans
Hypothalamus / drug effects*
Nicotine / pharmacology*
Receptors, Nicotinic / metabolism
Smoking
Grant Support
ID/Acronym/Agency:
CA79737/CA/NCI NIH HHS; NS22061/NS/NINDS NIH HHS; NS29071/NS/NINDS NIH HHS; R01 CA079737/CA/NCI NIH HHS; R01 NS022061/NS/NINDS NIH HHS; R01 NS022061-17/NS/NINDS NIH HHS; R01 NS022061-18/NS/NINDS NIH HHS; R01 NS022061-19/NS/NINDS NIH HHS; R01 NS022061-20/NS/NINDS NIH HHS; R01 NS022061-21/NS/NINDS NIH HHS; R01 NS029071/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Nicotinic; 54-11-5/Nicotine
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