Document Detail

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.
MedLine Citation:
PMID:  18429699     Owner:  NLM     Status:  MEDLINE    
Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates of NAD+ synthesis may be beneficial to protect against neurological degeneration, Candida glabrata infection, and possibly to enhance reverse cholesterol transport. The distinct and tissue-specific biosynthetic and/or ligand activities of tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible for vitamin-specific effects and side effects. Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research.
Katrina L Bogan; Charles Brenner
Related Documents :
7181239 - Pulmonary function and bronchial reactivity in human subjects with exposure to ozone an...
9347189 - Treatment of extraesophageal manifestations of gastroesophageal reflux disease.
2311969 - Value of the 24 hour intraoesophageal ph monitoring in children.
7095099 - Nicotine and ascorbic acid effects on cold-restraint ulcers in rats.
11374669 - Integrated acidity and the pathophysiology of gastroesophageal reflux disease.
17013449 - Update in the diagnosis of gastroesophageal reflux disease.
932429 - Studies on glycopeptide released by trypsin from sheep erythrocytes.
2018469 - Differential hepatic processing and biliary secretion of head-group and acyl chains of ...
19604939 - Amino acid inhibition of sodium-dependent synaptosomal proline uptake.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  28     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-30     Citation Subset:  IM    
Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Caloric Restriction
Candida glabrata / metabolism
Dietary Supplements
Dyslipidemias / blood,  drug therapy*
NAD / biosynthesis,  metabolism*
Niacin / metabolism*
Niacinamide / analogs & derivatives*,  metabolism*
Nutritional Requirements
Reg. No./Substance:
1341-23-7/nicotinamide-beta-riboside; 53-84-9/NAD; 59-67-6/Niacin; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulation of food intake through hypothalamic signaling networks involving mTOR.
Next Document:  A retrospective managed care claims data analysis of medication adherence to vaginal estrogen therap...