| Nicotinic acetylcholine receptor system and neuropsychiatric disorders. | |
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MedLine Citation:
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PMID: 15599803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigations into the neurobiology, and biophysical and pharmacological properties of nicotinic receptors, also known as nicotinic acetylcholine receptors (nAChRs), have led to an improved understanding of their role in a variety of neuropsychiatric disorders. There is a growing body of evidence linking alterations in nicotinic receptor number and/or function to conditions such as schizophrenia, Alzheimer's disease, Parkinson's disease, anxiety disorders, mood disorders, and attention deficit-hyperactivity disorder. The implications of nicotine receptor modulation upon the clinical expression and progression of these disorders is currently under investigation, utilizing techniques that include psychopharmacological, cognitive, electrophysiological and neuroimaging analysis. This review attempts to outline evidence pertaining to the role of the nicotinic receptor system in various neuropsychiatric disorders in the context of understanding appropriate targets for therapeutic drug development. |
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Authors:
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Abhay Singh; Alexandra Potter; Paul Newhouse |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: IDrugs : the investigational drugs journal Volume: 7 ISSN: 1369-7056 ISO Abbreviation: IDrugs Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-15 Completed Date: 2005-03-14 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100883655 Medline TA: IDrugs Country: England |
Other Details:
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Languages: eng Pagination: 1096-103 Citation Subset: IM |
Affiliation:
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Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine, 1 South Prospect Street, Burlington, VT 05401, USA. Abhay.Singh@uvm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Mental Disorders / metabolism* Neurodegenerative Diseases / metabolism* Receptors, Nicotinic / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Nicotinic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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