| Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog. | |
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MedLine Citation:
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PMID: 2645388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-two monoclonal antibodies (mAbs) generated against nicotinic acetylcholine receptors (AChRs) from electric organ were tested for their ability to cross-react in the optic tectum of the frog Rana pipiens. Twenty-eight of the mAbs tested (67%) bound to the optic neuropil of the tectum as revealed by immunoperoxidase cytochemistry. The pattern of peroxidase stain for cross-reacting mAbs corresponded in position to a subset of the retinotectal projections. Electron microscopic examination revealed that peroxidase reaction product was associated with the surface of vesicle-containing profiles but not with synaptic sites. Removal of one retina resulted in the loss of immunoreactivity in the contralateral tectum. AChR-like immunoreactivity was also associated with the optic tract and optic nerve and with retinal ganglion cells. These results indicate that some classes of retinal ganglion cells bear AChR-like molecules on their surface. The existence of these molecules on ganglion cell axons and terminals seems the most likely explanation for the AChR-like immunoreactivity present in the tectum. |
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Authors:
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P B Sargent; S H Pike; D B Nadel; J M Lindstrom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 9 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-04-03 Completed Date: 1989-04-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 565-73 Citation Subset: IM |
Affiliation:
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Division of Biomedical Sciences, University of California, Riverside 92521. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / diagnostic use Axons / metabolism Goldfish Immunoenzyme Techniques Rana pipiens Receptors, Nicotinic / metabolism* Retina / metabolism*, ultrastructure Retinal Ganglion Cells / metabolism Superior Colliculi / metabolism* Visual Pathways / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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NS 11323/NS/NINDS NIH HHS; NS 22491/NS/NINDS NIH HHS; NS 24207/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Receptors, Nicotinic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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