| Nicotinic acetylcholine receptor ligands, a patent review (2006-2011). | |
| | |
MedLine Citation:
|
PMID: 22098319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nicotinic acetylcholine receptors (nAChRs), pentameric ligand-gated cation channels, are potential targets for the development of therapeutics for a variety of disease states. AREAS COVERED: This article is reviewing recent advances in the development of small-molecule ligands for diverse nAChR subtypes and is a continuation of an earlier review in this journal. EXPERT OPINION: The development of nAChR ligands with preference for α4β2 or α7 subtypes for the treatment of central nervous system disorders are in the most advanced developmental stage. In addition, there is a fast growing interest to generate so-called PAMs, positive allosteric modulators, to influence the channels' functionalities. |
| | |
Authors:
|
Daniela Gündisch; Christoph Eibl |
Related Documents
:
|
15234349 - Sympathetic cholinergic target innervation requires gdnf family receptor gfr alpha 2. 7955319 - Growth cone collapse and neurite retraction from cultured helisoma neurons in response ... 15485769 - Retrograde propagation of gdnf-mediated signals in sympathetic neurons. 9133379 - Complementary and overlapping expression of glial cell line-derived neurotrophic factor... 10972289 - The drosophila netrin receptor frazzled guides axons by controlling netrin distribution. 22247749 - Gpr30 forms an integral part of e2-protective pathway in experimental autoimmune enceph... 3036529 - Receptor-mediated endocytosis of transferrin and ferritin by guinea-pig reticulocytes. ... 23330639 - Multiparametric homogeneous method for identification of ligand binding to gpcr: recept... 8187209 - The interaction of lp(a) with normal and ldl-receptor-deficient human skin fibroblasts. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Expert opinion on therapeutic patents Volume: 21 ISSN: 1744-7674 ISO Abbreviation: Expert Opin Ther Pat Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-21 Completed Date: 2012-03-26 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 9516419 Medline TA: Expert Opin Ther Pat Country: England |
Other Details:
|
Languages: eng Pagination: 1867-96 Citation Subset: IM |
Affiliation:
|
University of Hawai'i at Hilo, College of Pharmacy, Department of Pharmaceutical Sciences, 34 Rainbow Drive, Hilo, HI 96720, USA. danielag@hawaii.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Central Nervous System Agents / chemistry, pharmacology*, therapeutic use Cholinergic Agents / chemistry, pharmacology*, therapeutic use Drug Design Humans Ligands Molecular Structure Patents as Topic Receptors, Nicotinic / drug effects*, metabolism Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
|
P20 RR016467-11/RR/NCRR NIH HHS; P20RR016467/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Agents; 0/Cholinergic Agents; 0/Ligands; 0/Receptors, Nicotinic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Salicylic acid derivatives: synthesis, features and usage as therapeutic tools.
Next Document: Nuclear factor-kappa B inhibitors; a patent review (2006-2010).