Document Detail

Nicotine's attenuation of body weight involves the perifornical hypothalamus.
MedLine Citation:
PMID:  17655879     Owner:  NLM     Status:  MEDLINE    
Previously we showed that intermittent administration of nicotine (NIC) in the dark phase decreased food intake and body weight and this could be blocked when the NIC receptor antagonist mecamylamine was infused into the fourth ventricle. Catecholaminergic neurons adjacent to the fourth ventricle contain NIC receptors and directly innervate the perifornical hypothalamus (PFH) which has been shown to be involved in regulation of feeding. This study explored whether NIC regulates feeding behavior by modulating catecholaminergic input to the PFH. Epinephrine and norepinephrine neuronal input was ablated within the PFH by infusion of 6-hydroxydopamine hydrobromide (6-OHDA), while bupropion was infused to protect dopaminergic neurons. After recovery of body weights to pre-surgery levels, food intake, meal size, meal number and body weight were measured after intermittent NIC injections. The results showed the PFH lesioned animals did not exhibit the typical prolonged drop in food intake, meal size and body weight normally associated with NIC administration. High performance liquid chromatography analyses demonstrated that compared to control rats, 6-OHDA administration significantly reduced PFH norepinephrine and epinephrine levels, but not dopamine levels. These results are consistent with NIC reducing food intake in part by acting through catecholaminergic neurons within or extending through the PFH.
Phillip R Kramer; Guoqiang Guan; Paul J Wellman; Larry L Bellinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-28
Journal Detail:
Title:  Life sciences     Volume:  81     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-09-26     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  500-8     Citation Subset:  IM    
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M University System Health Science Center, 3302 Gaston Ave. Dallas, TX 75246, USA.
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MeSH Terms
Body Weight / drug effects*
Catecholamines / physiology
Eating / drug effects
Epinephrine / metabolism
Hypothalamus / drug effects*,  physiology*
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology*
Norepinephrine / metabolism
Oxidopamine / pharmacology
Rats, Sprague-Dawley
Sympathectomy, Chemical
Sympatholytics / pharmacology
Grant Support
R03 AG022196/AG/NIA NIH HHS; R03 AG022196-01/AG/NIA NIH HHS
Reg. No./Substance:
0/Catecholamines; 0/Nicotinic Agonists; 0/Sympatholytics; 1199-18-4/Oxidopamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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