Document Detail

Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells.
MedLine Citation:
PMID:  10555165     Owner:  NLM     Status:  MEDLINE    
The influence of nicotine on the expression of Fos family proteins, which specifically formed complexes with the AP-1 sequence, was assessed. mRNA for c-Fos, c-jun and jun-B were up-regulated at 0.5 h after nicotine treatment, elevated c-Fos also being apparent after withdrawal. Although nicotine failed to up-regulate the mRNA level of the fra-1 gene, the Fra- protein was highly expressed after both treatment and withdrawal. These results indicate that nicotine treatment may affect the transcriptional activity of many genes through c-Fos and c-Jun protein expression in neural cells, and that Fra-1 protein may make a contribution. These changes in immediately early genes (IEGs) may be associated with nicotine withdrawal symptoms.
N Ichino; H Ishiguro; K Yamada; K Nishii; H Sawada; T Nagatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience research     Volume:  35     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-02     Completed Date:  1999-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.
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MeSH Terms
Adrenal Gland Neoplasms
Amino Acid Sequence
Antisense Elements (Genetics)
Gene Expression Regulation, Neoplastic / drug effects,  physiology*
Genes, fos*
Genes, jun
Molecular Sequence Data
Nicotine / pharmacology*
Oligonucleotide Probes
PC12 Cells
Proto-Oncogene Proteins c-fos / chemistry,  genetics*
Proto-Oncogene Proteins c-jun / genetics
RNA, Messenger / genetics
Sequence Alignment
Sequence Homology, Amino Acid
Substance Withdrawal Syndrome
Transcription, Genetic / drug effects
Reg. No./Substance:
0/Antisense Elements (Genetics); 0/Oligonucleotide Probes; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 54-11-5/Nicotine

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