Document Detail

Nicotine withdrawal symptoms in adolescent and adult twins.
MedLine Citation:
PMID:  20707706     Owner:  NLM     Status:  MEDLINE    
We examined the variation and heritability of DSM-IV nicotine withdrawal (NW) in adult and adolescent male and female twin cigarette smokers (who reported smoking 100 or more cigarettes lifetime). Telephone diagnostic interviews were completed with 3,112 Australian adult male and female smokers (53% women; age: 24-36) and 702 Missouri adolescent male and female smokers (59% girls; age: 15-21). No gender or cohort differences emerged in rates of meeting criteria for NW (44%). Latent class analyses found that NW symptoms were best conceptualized as a severity continuum (three levels in adults and two levels in adolescents). Across all groups, increasing NW severity was associated with difficulty quitting, impairment following cessation, heavy smoking, depression, anxiety, conduct disorder and problems with alcohol use. NW was also associated with seeking smoking cessation treatment and with smoking persistence in adults. The latent class structure of NW was equally heritable across adult and adolescent smokers with additive genetic influences accounting for 49% of the variance and the remaining 51% of variance accounted for by unique environmental influences. Overall, findings suggest remarkable similarity in the pattern and heritability of NW across adult and adolescent smokers, and highlight the important role of NW in psychiatric comorbidity and the process of smoking cessation across both age groups.
Michele L Pergadia; Arpana Agrawal; Andrew C Heath; Nicholas G Martin; Kathleen K Bucholz; Pamela A F Madden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  13     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2011-02-24     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  359-69     Citation Subset:  IM    
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MeSH Terms
Cohort Studies
Nicotine / adverse effects*
Substance Withdrawal Syndrome / epidemiology,  genetics,  psychology*
Twins / psychology
Grant Support
AA07728/AA/NIAAA NIH HHS; AA09022/AA/NIAAA NIH HHS; AA10249/AA/NIAAA NIH HHS; AA11998/AA/NIAAA NIH HHS; AA12640/AA/NIAAA NIH HHS; AA13321/AA/NIAAA NIH HHS; DA019951/DA/NIDA NIH HHS; DA12540/DA/NIDA NIH HHS; DA12854/DA/NIDA NIH HHS; DA14363/DA/NIDA NIH HHS; DA23668/DA/NIDA NIH HHS; K05 AA017688/AA/NIAAA NIH HHS; K08 DA019951-05/DA/NIDA NIH HHS; P60 AA011998/AA/NIAAA NIH HHS; P60 AA011998-12/AA/NIAAA NIH HHS; R01 AA009022/AA/NIAAA NIH HHS; R01 AA009022-10/AA/NIAAA NIH HHS; R01 AA010249/AA/NIAAA NIH HHS; R01 AA010249-04/AA/NIAAA NIH HHS; R01 AA012640/AA/NIAAA NIH HHS; R01 AA012640-09/AA/NIAAA NIH HHS; R01 AA013321/AA/NIAAA NIH HHS; R01 AA013321-05/AA/NIAAA NIH HHS; R01 AA017915/AA/NIAAA NIH HHS; R01 DA012540/DA/NIDA NIH HHS; R01 DA012540-05/DA/NIDA NIH HHS; R01 DA012854/DA/NIDA NIH HHS; R01 DA012854-08/DA/NIDA NIH HHS; R01 DA014363/DA/NIDA NIH HHS; R01 DA014363-09/DA/NIDA NIH HHS; R01 DA023668/DA/NIDA NIH HHS; R01 DA023668-04/DA/NIDA NIH HHS; R37 AA007728/AA/NIAAA NIH HHS; R37 AA007728-20/AA/NIAAA NIH HHS; //Medical Research Council
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