Document Detail

Nicotine withdrawal among adolescents with acute psychopathology: an item response analysis.
MedLine Citation:
PMID:  15203788     Owner:  NLM     Status:  MEDLINE    
The present study explored the relationship between psychopathology and the experience of nicotine withdrawal among 191 adolescent smokers deprived of nicotine during a psychiatric hospitalization. Using methods based in item response theory, we demonstrated the ability of symptoms of nicotine withdrawal to cohere in measuring the withdrawal syndrome. After controlling for nicotine dependence, we found that several disorders showed significant but modest univariate relationships with individual withdrawal symptoms. After controlling for comorbidity with other disorders, we found that depressive and conduct disorders maintained significant but modest relationships with increased withdrawal severity. Item analyses across groups suggested that girls, individuals with a depressive disorder, and individuals with a conduct disorder tended to report higher levels of nicotine withdrawal but did not appear to inflate their scores because of disorder- or gender-specific reporting bias. Although levels of acute distress were related to withdrawal severity, the six-item withdrawal index showed good discriminant validity in this sample by demonstrating stronger correlations with craving and level of dependence than could be accounted for by levels of distress alone.
David R Strong; Christopher W Kahler; Susan E Ramsey; Ana Abrantes; Richard A Brown
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  6     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-10-05     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  547-57     Citation Subset:  IM    
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MeSH Terms
Adolescent Behavior*
Conduct Disorder / complications,  psychology*
Depressive Disorder / complications,  psychology*
Hospitals, Psychiatric
Smoking Cessation*
Substance Withdrawal Syndrome / psychology*
Tobacco Use Disorder / psychology*
Grant Support
CA77082/CA/NCI NIH HHS; R01 CA077082/CA/NCI NIH HHS; R01 CA077082-04/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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