Document Detail


Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial.
MedLine Citation:
PMID:  22123796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Rates of smoking cessation have not changed in a decade, accentuating the need for novel approaches to prompt quit attempts.
METHODS: Within a nationwide randomized clinical trial (N = 849) to induce further quit attempts and cessation, smokers currently unmotivated to quit were randomized to a practice quit attempt (PQA) alone or to nicotine replacement therapy (hereafter referred to as nicotine therapy), sampling within the context of a PQA. Following a 6-week intervention period, participants were followed up for 6 months to assess outcomes. The PQA intervention was designed to increase motivation, confidence, and coping skills. The combination of a PQA plus nicotine therapy sampling added samples of nicotine lozenges to enhance attitudes toward pharmacotherapy and to promote the use of additional cessation resources. Primary outcomes included the incidence of any ever occurring self-defined quit attempt and 24-hour quit attempt. Secondary measures included 7-day point prevalence abstinence at any time during the study (ie, floating abstinence) and at the final follow-up assessment.
RESULTS: Compared with PQA intervention, nicotine therapy sampling was associated with a significantly higher incidence of any quit attempt (49% vs 40%; relative risk [RR], 1.2; 95% CI, 1.1-1.4) and any 24-hour quit attempt (43% vs 34%; 1.3; 1.1-1.5). Nicotine therapy sampling was marginally more likely to promote floating abstinence (19% vs 15%; RR, 1.3; 95% CI, 1.0-1.7); 6-month point prevalence abstinence rates were no different between groups (16% vs 14%; 1.2; 0.9-1.6).
CONCLUSION: Nicotine therapy sampling during a PQA represents a novel strategy to motivate smokers to make a quit attempt.
TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00706979.
Authors:
Matthew J Carpenter; John R Hughes; Kevin M Gray; Amy E Wahlquist; Michael E Saladin; Anthony J Alberg
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of internal medicine     Volume:  171     ISSN:  1538-3679     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-01-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1901-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry, Hollings Cancer Center, Medical University of South Carolina, Charleston, 29425, USA. carpente@musc.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00706979
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Male
Middle Aged
Motivation*
Nicotine / administration & dosage*
Nicotinic Agonists / administration & dosage*
Smoking Cessation / methods*,  psychology
Tobacco Use Cessation Products*
Grant Support
ID/Acronym/Agency:
K05DA000490/DA/NIDA NIH HHS; K12DA000357/DA/NIDA NIH HHS; K23 DA020482/DA/NIDA NIH HHS; K23DA020482/DA/NIDA NIH HHS; R01 DA021619/DA/NIDA NIH HHS; R01DA021619/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine
Comments/Corrections
Comment In:
Arch Intern Med. 2011 Nov 28;171(21):1907-9   [PMID:  22123797 ]
Evid Based Med. 2012 Dec;17(6):187-8   [PMID:  22736669 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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