Document Detail


Nicotine: a precursor for carcinogens.
MedLine Citation:
PMID:  3971354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eric Boyland and collaborator demonstrated about 20 years ago that N'-nitrosonornicotine (NNN), a suspected smoke constituent, was a lung carcinogen in mice and that thiocyanate, a major detoxification product of the smoke component hydrogen cyanide, catalyzes the endogenous formation of nitrosamines. Also, Boyland presumed that the enzymatic conversion of nicotine may contribute to the carcinogenic potential of cigarette smoke via reactive intermediates. Chemical, biochemical and bioassay data gathered since these first observations, support the concept that the nicotine-derived NNN and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) contribute significantly to the carcinogenic activity of snuff and cigarette smoke. Reactive metabolites of nicotine may also be carcinogenic factors. This hypothesis requires exploration.
Authors:
D Hoffmann; E J Lavoie; S S Hecht
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  26     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-04-17     Completed Date:  1985-04-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Carcinogens* / metabolism
Cotinine / metabolism
Humans
Lung Neoplasms / chemically induced
Nicotine / metabolism,  toxicity*
Nitrosamines / toxicity*
Plants, Toxic
Rats
Smoking
Tobacco
Grant Support
ID/Acronym/Agency:
CA-21393/CA/NCI NIH HHS; CA-29580/CA/NCI NIH HHS; CA-35607/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Nitrosamines; 486-56-6/Cotinine; 54-11-5/Nicotine; 64091-91-4/4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; 80508-23-2/N'-nitrosonornicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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