| Nicotine: a precursor for carcinogens. | |
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MedLine Citation:
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PMID: 3971354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eric Boyland and collaborator demonstrated about 20 years ago that N'-nitrosonornicotine (NNN), a suspected smoke constituent, was a lung carcinogen in mice and that thiocyanate, a major detoxification product of the smoke component hydrogen cyanide, catalyzes the endogenous formation of nitrosamines. Also, Boyland presumed that the enzymatic conversion of nicotine may contribute to the carcinogenic potential of cigarette smoke via reactive intermediates. Chemical, biochemical and bioassay data gathered since these first observations, support the concept that the nicotine-derived NNN and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) contribute significantly to the carcinogenic activity of snuff and cigarette smoke. Reactive metabolites of nicotine may also be carcinogenic factors. This hypothesis requires exploration. |
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Authors:
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D Hoffmann; E J Lavoie; S S Hecht |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer letters Volume: 26 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-04-17 Completed Date: 1985-04-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Carcinogens* / metabolism Cotinine / metabolism Humans Lung Neoplasms / chemically induced Nicotine / metabolism, toxicity* Nitrosamines / toxicity* Plants, Toxic Rats Smoking Tobacco |
| Grant Support | |
ID/Acronym/Agency:
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CA-21393/CA/NCI NIH HHS; CA-29580/CA/NCI NIH HHS; CA-35607/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Nitrosamines; 486-56-6/Cotinine; 54-11-5/Nicotine; 64091-91-4/4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; 80508-23-2/N'-nitrosonornicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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