Document Detail

Nicotine patch and lozenge are effective for women.
MedLine Citation:
PMID:  15804684     Owner:  NLM     Status:  MEDLINE    
It has been hypothesized that women may be less likely to obtain therapeutic benefit from nicotine replacement therapy (NRT). The present study tested this hypothesis, using two different types of NRT medications. A secondary analysis of two randomized clinical trials was performed: One compared active 21-mg nicotine patch with placebo among 193 men and 309 women, and the other compared active 2-mg or 4-mg nicotine lozenge with placebo among 788 men and 1,030 women. Using logistic regression analysis of 6-month continuous abstinence and survival analysis, we assessed the efficacy of patch and lozenge among women and tested for a gender x treatment interaction. Active NRT was more effective than placebo among women, for both patch and lozenge. In the lozenge trial, women were less successful than men. The gender x treatment interaction was not significant in either study, whether assessed by logistic regression or survival analysis. In the lozenge trial, gender moderated the effects of smoking rate and dependence (but not treatment) on outcome: These variables affected success rates only among women. Treatment with nicotine patch or lozenge is effective for women, and the analysis did not reveal significant gender differences in efficacy. Gender differences in outcome may be moderated by nicotine dependence.
Saul Shiffman; Christine T Sweeney; Carolyn M Dresler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  7     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Pinney Associates and University of Pittsburgh, Pittsburgh, PA 15213, USA.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Central Nervous System Stimulants / administration & dosage*
Great Britain
Logistic Models
Middle Aged
Nicotine / administration & dosage*,  analogs & derivatives*
Polymethacrylic Acids / administration & dosage*
Polyvinyls / administration & dosage*
Proportional Hazards Models
Randomized Controlled Trials as Topic
Retrospective Studies
Smoking / drug therapy*
Smoking Cessation / methods*
Time Factors
Treatment Outcome
United States
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Polymethacrylic Acids; 0/Polyvinyls; 54-11-5/Nicotine; 96055-45-7/nicotine polacrilex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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