Document Detail

Nicotine microaerosol inhaler.
MedLine Citation:
PMID:  10623787     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure the droplet size distribution of a nicotine pressurized metered-dose inhaler using a nicotine in ethanol solution formulation with hydrofluoroalkane as propellant. MATERIALS AND METHODS: Sizing was performed at room temperature by multistage liquid impinger and quartz crystal impactor. RESULTS: The mass median aerodynamic diameter of the nicotine aerosol produced was measured at 1.6 mm by multistage liquid impinger and 1.5 mm by quartz crystal impactor. CONCLUSIONS: The inhaler formulation used produces a microaerosol of sufficiently fine droplet size that mimics the puff-by-puff pulmonary arterial bolus nicotine delivery of tobacco smoke. The absence of combustion products such as heat, carcinogens and carbon monoxide permits safer nicotine delivery via the inhaler than is possible via smoked tobacco.
P G Andrus; R Rhem; J Rosenfeld; M B Dolovich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian respiratory journal : journal of the Canadian Thoracic Society     Volume:  6     ISSN:  1198-2241     ISO Abbreviation:  Can. Respir. J.     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433332     Medline TA:  Can Respir J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Aerosol Research Laboratory, McMaster University, Hamilton, Canada. andrusp@fhs.csu.McMaster.CA
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MeSH Terms
Aerosol Propellants / administration & dosage
Hydrocarbons, Fluorinated / administration & dosage
Nebulizers and Vaporizers*
Nicotine / administration & dosage*
Particle Size
Reg. No./Substance:
0/Aerosol Propellants; 0/Aerosols; 0/Hydrocarbons, Fluorinated; 0/Solutions; 431-89-0/HFA 134a; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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